Effect of different protocols on the mitigation of exercise‐induced pulmonary hemorrhage in horses when administered 24 hours before strenuous exercise
| Autor: | Warwick M. Bayly, Jenifer R. Gold, Debra C. Sellon, Carolina Lopez, Gerald Bergsma, R. H. Sides, Jenyka Bergsma |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Lung Diseases
Male 040301 veterinary sciences Strenuous exercise Exercise-induced pulmonary hemorrhage racetrack Hemorrhage Standard Article 030204 cardiovascular system & hematology Placebo 0403 veterinary science 03 medical and health sciences 0302 clinical medicine medicine Animals bronchoalveolar lavage Horses furosemide Treadmill endoscopy Diuretics Cross-Over Studies lcsh:Veterinary medicine General Veterinary medicine.diagnostic_test business.industry Furosemide 04 agricultural and veterinary sciences medicine.disease bleeding Crossover study Standard Articles Bronchoalveolar lavage Anesthesia treadmill Respiratory Erythrocyte Count horseracing lcsh:SF600-1100 Female Horse Diseases Pulmonary hemorrhage EQUID business Bronchoalveolar Lavage Fluid water consumption medicine.drug |
| Zdroj: | Journal of Veterinary Internal Medicine, Vol 33, Iss 5, Pp 2319-2326 (2019) Journal of Veterinary Internal Medicine |
| ISSN: | 0891-6640 1939-1676 |
| Popis: | Background Public pressure exists in the United States to eliminate race-day furosemide administration despite its efficacy in decreasing the severity of equine exercise pulmonary hemorrhage (EIPH). No effective alternative prophylaxis strategies have been identified. Objective To investigate alternative protocols to race-day furosemide that might mitigate EIPH. Animals Seven fit Thoroughbreds with recent EIPH. Methods Double-blinded placebo-controlled Latin square crossover using a treadmill followed by a blinded placebo-controlled crossover study at a racetrack. First, horses exercised supramaximally to fatigue 24 hours after initiating 5 EIPH prophylaxis protocols: 0.5 and 1.0 mg/kg furosemide IV 24 hours pre-exercise with and without controlled access to water, and 24 hour controlled access to water. Effects were compared to those measured after giving a placebo 24 hours pre-exercise, and 0.5 mg/kg furosemide IV 4 hours pre-exercise. Bronchoalveolar lavage (BAL) erythrocyte count was determined 45-60 minutes postexercise after endoscopy to assign an EIPH score. Data were analyzed using linear mixed effects models. The most promising protocol from the treadmill study was further evaluated in 6 horses using endoscopy and BAL after 1100 m simulated races. Results Intravenous furosemide (0.5 mg/kg) administered 24 hours pre-exercise combined with controlled access to water decreased the severity of EIPH on the treadmill and at the racetrack. Conclusion and clinical importance Administering 0.5 mg/kg furosemide 24 hours pre-racing combined with controlling water intake may be a strategy to replace race-day furosemide administration for the management of EIPH. A larger study is indicated to further evaluate whether this protocol significantly mitigates EIPH severity. |
| Databáze: | OpenAIRE |
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