Secondary Squamous Cell Carcinoma of the Oral Cavity after Nasopharyngeal Carcinoma
| Autor: | Liyuan Dai, Xu Zhang, Peng Li, Qigen Fang, Junfu Wu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine Oncology Cancer Research medicine.medical_specialty Lymphovascular invasion Perineural invasion Secondary squamous cell carcinoma 03 medical and health sciences 0302 clinical medicine Internal medicine Humans Medicine Stage (cooking) Survival analysis Aged Neoplasm Staging Proportional Hazards Models Nasopharyngeal Carcinoma Radiotherapy business.industry Proportional hazards model Head and neck squamous cell carcinoma Neoplasms Second Primary Middle Aged Prognosis medicine.disease Head and neck squamous-cell carcinoma Primary tumor stomatognathic diseases 030104 developmental biology Oral squamous cell carcinoma Nasopharyngeal carcinoma 030220 oncology & carcinogenesis Carcinoma Squamous Cell Original Article Female Mouth Neoplasms Disease Susceptibility business |
| Zdroj: | Cancer Research and Treatment : Official Journal of Korean Cancer Association |
| ISSN: | 2005-9256 1598-2998 |
| DOI: | 10.4143/crt.2019.202 |
| Popis: | Purpose The main goal of this study was to analyze the prognosis of secondary oral squamous cell carcinoma (SCC) with a comparison with sporadic oral SCC by a matched-pair design. Materials and Methods Records of patients with surgically treated primary oral SCC were reviewed, and a total of 83 patients with previous history of radiotherapy for nasopharyngeal carcinoma (NPC) were retrospectively enrolled. A matched-pair study was performed, each NPC survivor was matched with two sporadic oral SCC patients by age, sex, primary tumor site, adverse pathologic characteristics, disease stage, neck node status, and tumor stage. The overall survival (OS) and disease-specific survival (DSS) rates were calculated by the Kaplan-Meier method; independent prognostic factors were evaluated by the Cox proportional hazards method. Results Compared with sporadic oral SCC patients, NPC survivors were less likely to be smokers (p=0.004), perineural invasion and lymphovascular invasion were more common in NPC survivors (both p < 0.001). The 5-year OS and DSS rates in NPC survivors were 47% and 54%, respectively; the 5-year OS and DSS rates in sporadic oral SCC patients were 62% and 67%, respectively; the difference was significant (both p < 0.05). In survival analysis, disease stage remained to be independent prognostic factor for both the OS and DSS. Conclusion NPC survivors had worse OS and DSS than sporadic oral SCC patients, NPC survivors were less likely to be smokers, but had higher opportunity of perineural invasion and lymphovascular invasion. Disease stage was the most important predictor for the survival in NPC survivors. |
| Databáze: | OpenAIRE |
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