Glucuronidation of oxygenated benzo(a)pyrene derivatives by UDP-glucuronyltransferase of nuclear envelope
| Autor: | Jan Zaleski, Teresa Gessner, Surendra K. Bansal |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Male
Nuclear Envelope Stereochemistry Biophysics Glucuronidation Biochemistry Substrate Specificity chemistry.chemical_compound polycyclic compounds medicine Animals Transferase Phenols Benzopyrenes Glucuronosyltransferase Nuclear membrane Molecular Biology Cell Biology Compartment (chemistry) Rats Kinetics medicine.anatomical_structure Liver chemistry Benzo(a)pyrene Microsomes Liver Microsome Pyrene |
| Zdroj: | Biochemical and Biophysical Research Communications. 98:131-139 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/0006-291x(81)91879-9 |
| Popis: | Several benzo(a)pyrene phenols, dihydrodiols, epoxides, quinones, and a diolepoxide were tested as possible substrates for UDP-glucuronyltransferase located in rat liver nuclear envelope fraction. Only phenolic derivatives of benzo(a)pyrene served as substrates for the nuclear membrane transferase, under the conditions tested. The specific activities observed in nuclear envelope preparations were greater than or equal to, those of the microsomal fraction indicating that a very effective detoxication mechanism for these phenols is present in the nuclear compartment. |
| Databáze: | OpenAIRE |
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