Relative Carnitine Deficiency in Autism
| Autor: | Jenifer Juranek, Minh T. Nguyen, Christa Cummings, J. Jay Gargus, Pauline A. Filipek |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Alanine levels Mitochondrial disease Carnitine Internal medicine Pyruvic Acid Developmental and Educational Psychology medicine Humans Hyperammonemia Lactic Acid Autistic Disorder Child Retrospective Studies Alanine medicine.disease Diagnostic and Statistical Manual of Mental Disorders Developmental disorder Endocrinology Child Preschool Lactic acidosis Autism Female Psychology medicine.drug |
| Zdroj: | Journal of Autism and Developmental Disorders. 34:615-623 |
| ISSN: | 1573-3432 0162-3257 |
| DOI: | 10.1007/s10803-004-5283-1 |
| Popis: | A random retrospective chart review was conducted to document serum carnitine levels on 100 children with autism. Concurrently drawn serum pyruvate, lactate, ammonia, and alanine levels were also available in many of these children. Values of free and total carnitine (p < 0.001), and pyruvate (p = 0.006) were significantly reduced while ammonia and alanine levels were considerably elevated (p < 0.001) in our autistic subjects. The relative carnitine deficiency in these patients, accompanied by slight elevations in lactate and significant elevations in alanine and ammonia levels, is suggestive of mild mitochondrial dysfunction. It is hypothesized that a mitochondrial defect may be the origin of the carnitine deficiency in these autistic children. |
| Databáze: | OpenAIRE |
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