Association Between Familial Hypercholesterolemia and Prevalence of Type 2 Diabetes Mellitus
| Autor: | Joep C. Defesche, Barbara A. Hutten, Joost Besseling, John J.P. Kastelein, G. Kees Hovingh |
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| Přispěvatelé: | 01 Internal and external specialisms, ACS - Amsterdam Cardiovascular Sciences, Vascular Medicine, Experimental Vascular Medicine, Epidemiology and Data Science |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Apolipoprotein B Familial hypercholesterolemia Type 2 diabetes Gastroenterology Hyperlipoproteinemia Type II chemistry.chemical_compound Insulin-Secreting Cells Diabetes mellitus Internal medicine Prevalence medicine Humans Registries Netherlands biology business.industry Cholesterol Type 2 Diabetes Mellitus Confounding Factors Epidemiologic Cholesterol LDL General Medicine Middle Aged medicine.disease Cross-Sectional Studies Logistic Models Endocrinology Diabetes Mellitus Type 2 Receptors LDL chemistry Mutation LDL receptor biology.protein Female lipids (amino acids peptides and proteins) business |
| Zdroj: | JAMA, 313(10), 1029-1036. American Medical Association |
| ISSN: | 0098-7484 |
| Popis: | IMPORTANCE Familial hypercholesterolemia is characterized by impaired uptake of cholesterol in peripheral tissues, including the liver and the pancreas. In contrast, statins increase the cellular cholesterol uptake and are associated with increased risk for type 2 diabetes mellitus. We hypothesize that transmembrane cholesterol transport is linked to the development of type 2 diabetes. OBJECTIVE To assess the association between type 2 diabetes prevalence and familial hypercholesterolemia. DESIGN, SETTING, AND PARTICIPANTS Cross-sectional study in all individuals (n = 63 320) who underwent DNA testing for familial hypercholesterolemia in the national Dutch screening program between 1994 and 2014. EXPOSURES Deleteriousness and nondeleteriousness of familial hypercholesterolemia mutations were based on literature or laboratory function testing. Low-density lipoprotein (LDL) receptor mutations were considered more severe than apolipoprotein B gene (APOB) mutations, and receptor-negative LDL receptor mutations were considered more severe than receptor-deficient mutations. MAIN OUTCOMES AND MEASURES Prevalence of type 2 diabetes. RESULTS The prevalence of type 2 diabetes was 1.75% in familial hypercholesterolemia patients (n = 440/25 137) vs 2.93% in unaffected relatives (n = 1119/38 183) (P |
| Databáze: | OpenAIRE |
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