Left ventricle remodeling in patients with β-thalassemia major. An emerging differential diagnosis with left ventricle noncompaction disease
| Autor: | Donato Mele, Marianna Nardozza, Alessia Pepe, Elisabetta Chiodi, Massimo Lombardi, Giorgio Benea, Maria Rita Gamberini |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Heart Ventricles Cardiomyopathy Diastole Magnetic Resonance Imaging Cine Disease 030204 cardiovascular system & hematology Ventricular Function Left 030218 nuclear medicine & medical imaging Diagnosis Differential 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine medicine Humans Radiology Nuclear Medicine and imaging In patient Aged Aged 80 and over Isolated Noncompaction of the Ventricular Myocardium medicine.diagnostic_test Ventricular Remodeling business.industry beta-Thalassemia Magnetic resonance imaging Middle Aged medicine.disease medicine.anatomical_structure Ventricle Heart failure Cardiology Female Differential diagnosis business |
| Popis: | To differentiate left ventricle non-compaction (LVNC) from hypertrabeculated myocardium due to LV remodeling in β-thalassemia major (β-TM) patients, cardiac magnetic resonance (CMR) images of 38 β-TM patients and 10 LVNC patients were compared using 3 diagnostic criteria: ratio of diastolic segmental non-compacted to compacted myocardium (NC/C ratio) > 2.5, percentage of non-compacted LV mass (NC-LVM%) > 20% and > 25% of global LV mass. Specificity of NC/C ratio of > 2.5 was the lowest (58%) and of NC-LVM% of > 25% the highest (93%). A NC-LVM% > 20% showed sensitivity 100% and specificity 87%. Disease differentiation depends on the selected CMR criterion and is better with NC-LVM%. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|