Literature Review and Our Experience With Bleomycin-Based Electrochemotherapy for Cutaneous Vulvar Metastases From Endometrial Cancer
| Autor: | Gregor Vivod, Sebastjan Merlo, Maja Čemažar, Simona Kranjc Brezar, Nina Kovačević, Masa Bosnjak, Gregor Sersa, Sonja Bebar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
Electrochemotherapy Skin Neoplasms medicine.medical_treatment Review Carboplatin chemistry.chemical_compound 0302 clinical medicine skin metastases Antineoplastic Combined Chemotherapy Protocols cutaneous metastases bleomicin 030212 general & internal medicine RC254-282 Antibiotics Antineoplastic Vulvar Neoplasms bleomycin Incidence (epidemiology) Neoplasms. Tumors. Oncology. Including cancer and carcinogens Middle Aged metastaze na koži rak endometrija Oncology 030220 oncology & carcinogenesis endometrial cancer Female medicine.medical_specialty Paclitaxel Salpingo-oophorectomy Adenocarcinoma Hysterectomy Malignancy Bleomycin 03 medical and health sciences medicine Carcinoma Humans elektrokemoterapija udc:618.1 Chemotherapy business.industry Endometrial cancer medicine.disease Dermatology Endometrial Neoplasms Radiation therapy electrochemotherapy chemistry Dose Fractionation Radiation Neoplasm Recurrence Local business |
| Zdroj: | Technology in Cancer Research & Treatment, Vol 20 (2021) Technology in cancer research and treatment, vol. 20, 2021. Technology in Cancer Research & Treatment |
| ISSN: | 1533-0338 |
| Popis: | Endometrial carcinoma is the most common gynecological malignancy and the fifth most common malignancy in women. The worldwide incidence is 15.9 new cases per 100,000 women per year, and the incidence in Europe is 22.7 new cases. Minority of cases are diagnosed at an advanced stage of the disease. Cutaneous metastases are very rare with a prevalence of 0.8%. If cutaneous metastases are present, the prognosis is poor with an overall survival of up to 12 months. In this review, we presented clinical data on treatment of gynecological cancers with electrochemotherapy, with focus on treatment of cutaneous vulvar metastases from endometrial cancer. Further, we present our data on the case of a 64-year-old woman with recurrent endometrial adenocarcinoma with vulvar skin metastases. Treatment of endometrial carcinoma metastases is multimodal with surgery, chemotherapy, radiotherapy and hormone treatment. There is still no consensus about the specific treatment of cutaneous metastases from endometrial cancer, in particular in order to release symptoms. Electrochemotherapy may be a treatment option to reduce pain and bleeding and a safe option to treat multiple skin metastases. |
| Databáze: | OpenAIRE |
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