Lack of effects of fish oil supplementation for 12 weeks on resting metabolic rate and substrate oxidation in healthy young men: A randomized controlled trial
| Autor: | Stephanie Michelle Boville, Lawrence L. Spriet, Sebastian Jannas-Vela, David M. Mutch, Kaitlin Roke |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Erythrocytes Cell Membranes lcsh:Medicine Biochemistry law.invention 0302 clinical medicine Randomized controlled trial law Plant Products Medicine and Health Sciences Membrane Metabolism lcsh:Science Musculoskeletal System chemistry.chemical_classification Multidisciplinary Organic Compounds Muscles Fatty Acids Chemical Reactions Agriculture Fish oil Lipids Eicosapentaenoic acid Healthy Volunteers 3. Good health Chemistry Eicosapentaenoic Acid Docosahexaenoic acid Physical Sciences Carbohydrate Metabolism Seasons Anatomy Cellular Structures and Organelles Oxidation-Reduction Research Article Adult Docosahexaenoic Acids Carbohydrates 030209 endocrinology & metabolism Biology Carbohydrate metabolism Vegetable Oils 03 medical and health sciences Fish Oils Animal science Oxidation Humans Olive Oil 030109 nutrition & dietetics lcsh:R Organic Chemistry Chemical Compounds Biology and Life Sciences Fatty acid Cell Biology Carbohydrate Agronomy Metabolism Skeletal Muscles chemistry Dietary Supplements Basal metabolic rate lcsh:Q Basal Metabolism Oils Crop Science |
| Zdroj: | PLoS ONE PLoS ONE, Vol 12, Iss 2, p e0172576 (2017) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0172576 |
| Popis: | Fish oil (FO) has been shown to have beneficial effects in the body via incorporation into the membranes of many tissues. It has been proposed that omega-3 fatty acids in FO may increase whole body resting metabolic rate (RMR) and fatty acid (FA) oxidation in human subjects, but the results to date are equivocal. The purpose of this study was to investigate the effects of a 12 week FO supplementation period on RMR and substrate oxidation, in comparison to an olive oil (OO) control group, in young healthy males (n = 26; 22.8 ± 2.6 yr). Subjects were matched for age, RMR, physical activity, VO2max and body mass, and were randomly separated into a group supplemented with either OO (3 g/d) or FO containing 2 g/d eicosapentaenoic acid (EPA) and 1 g/d docosahexaenoic acid (DHA). Participants visited the lab for RMR and substrate oxidation measurements after an overnight fast (10–12 hr) at weeks 0, 6 and 12. Fasted blood samples were taken at baseline and after 12 weeks of supplementation. There were significant increases in the EPA (413%) and DHA (59%) levels in red blood cells after FO supplementation, with no change of these fatty acids in the OO group. RMR and substrate oxidation did not change after supplementation with OO or FO after 6 and 12 weeks. Since there was no effect of supplementation on metabolic measures, we pooled the two treatment groups to determine whether there was a seasonal effect on RMR and substrate oxidation. During the winter season, there was an increase in FA oxidation (36%) with a concomitant decrease (34%) in carbohydrate (CHO) oxidation (p < 0.01), with no change in RMR. These measures were unaffected during the summer season. In conclusion, FO supplementation had no effect on RMR and substrate oxidation in healthy young males. Resting FA oxidation was increased and CHO oxidation reduced over a 12 week period in the winter, with no change in RMR. Trial Registration: ClinicalTrials.gov {"type":"clinical-trial","attrs":{"text":"NCT02092649","term_id":"NCT02092649"}}NCT02092649 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|