Protective role of Decylubiquinone against secondary melanoma at lung in B16F10 induced mice by reducing E-cadherin expression and ameliorating ROCKII-Limk1/2-Cofiliin mediated metastasis

Autor:	Sujan Chatterjee, Debajyoti Patra, Pujita Ghosh, Soumi Banerjee, Snehasis Mishra, Pratip Chakraborty, Kaustav Dutta Chowdhury, Anupam Basu, Gobinda Chandra Sadhukhan
Rok vydání:	2023
Předmět:	Lung Neoplasms Melanoma Experimental Cell Biology Cadherins Actins Mice Inbred C57BL Mice Cell Movement Cell Line Tumor Animals Neoplasm Metastasis Reactive Oxygen Species Melanoma Lung
Zdroj:	Cellular Signalling. 101:110486
ISSN:	0898-6568
DOI:	10.1016/j.cellsig.2022.110486
Popis:	Melanoma is one of the most consequential skin cancer with a rising death incidences. Silent but belligerent nature of metastatic sprouting is the leading cause of melanoma related mortality. Invasion of metastatic cells and re-expression of E-Cadherin play the crucial role in the establishment of secondary tumor at distal sites. Thus, manipulation of tumor cell invasion in parallel to regulation of E-Cadherin expression can be considered as potential anti-metastatic strategy. Evidences suggested key role of reactive oxygen species associated ROCK activities in the modulation of metastatic invasion via F-actin stabilization. Here, we first-time report Decylubiquinone, a dietary Coenzyme Q
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::715183debd7d9363323ec20f2b51342c https://doi.org/10.1016/j.cellsig.2022.110486 Zobrazit plný text záznamu Full Text from ScienceDirect