Citrinin affects the oxidative metabolism of BHK-21 cells
Autor: | Ma. Benigna M. Oliveira, Generoso M. Chagas, Annibal P. Campello, Ma. Lúcia W. Klüppel |
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Rok vydání: | 1995 |
Předmět: |
animal structures
Respiratory rate Cell Respiration Clinical Biochemistry Respiratory chain chemistry.chemical_element Biology Kidney Biochemistry Oxygen Oxidative Phosphorylation Cell Line chemistry.chemical_compound Cricetinae Baby hamster kidney cell Animals Glycolysis Mycotoxin Cell Biology General Medicine Citrinin Mitochondria Glucose chemistry Energy Metabolism Anaerobic exercise |
Zdroj: | Cell Biochemistry and Function. 13:267-271 |
ISSN: | 1099-0844 0263-6484 |
DOI: | 10.1002/cbf.290130407 |
Popis: | The effects of citrinin on energy production along the respiratory chain and on glycolytic lactate production were examined in BHK-21 cultured cells. Citrinin inhibited the oxygen consumption rate by about 45 per cent. The respiratory rate of digitonin-treated cells energized with succinate, in the presence of ADP, was reduced by about 39 per cent. The mycotoxin inhibited the glucose utilization of BHK-21 cells by about 86 per cent. Cells treated with citrinin produced a small quantity of pyruvate, but were unable to produce lactate. It is concluded that BHK-21 cells cannot generate lactate when oxidative metabolism is inhibited by citrinin. The perturbations in BHK-21 cells caused by citrinin are due to alterations in mitochondrial function and in the glycolytic anaerobic pathway. |
Databáze: | OpenAIRE |
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