Calorie restriction and synbiotics effect on quality of life and edema reduction in breast cancer-related lymphedema, a clinical trial
| Autor: | Shahpar Haghighat, Mitra Zarrati, Saeideh Vafa, Marjan Malakootinejad, Farid Zayeri, Vahid Sanati, Ali Saneei Totmaj, Masoud Salehi |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Quality of life medicine.medical_specialty Adolescent Breast Cancer Lymphedema Breast Neoplasms Synbiotics Overweight Placebo lcsh:RC254-282 Body Mass Index 03 medical and health sciences Young Adult 0302 clinical medicine Breast cancer Internal medicine Edema medicine Humans 030212 general & internal medicine Obesity Lymphedema Calorie restriction Aged Caloric Restriction business.industry General Medicine Middle Aged medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Combined Modality Therapy Clinical trial Treatment Outcome 030220 oncology & carcinogenesis Surgery Female Original Article medicine.symptom business Body mass index |
| Zdroj: | Breast, Vol 54, Iss, Pp 37-45 (2020) The Breast : Official Journal of the European Society of Mastology |
| ISSN: | 1532-3080 |
| Popis: | Background: Little evidence exists regarding the clinical value of synbiotics in the management of post-treatment complications of breast cancer especially breast cancer-related lymphedema (BCRL). This study aimed to investigate the effects of synbiotic supplementation along with calorie restriction on quality of life and edema volume in patients with BCRL. Methods: This randomized, placebo-controlled, clinical trial was conducted on 135 overweight and obese women with BCRL aged 18–65 years old. Participants were randomly allocated to receive a calorie-restricted diet plus 109 CFU synbiotic supplement (CRS group; n = 45) or placebo (CRP group; n = 45), daily for 10 weeks. Also, a control group (n = 45) with no intervention was included in the trial. All of the participants received Complete Decongestive Therapy for lymphedema treatment. The quality of life score, edema volume and body mass index (BMI) were measured at baseline and end of the trial. Results: A total of 121 subjects completed the trial. CRS group showed a significant decrease in the total quality of life score (P = 0.004), and it’s psychosocial (P = 0.022) and functional (P = 0.002) domain scores, as well as edema volume (P = 0.002) and BMI (P |
| Databáze: | OpenAIRE |
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