Odontogenic Carcinosarcoma: Clinicopathologic Features of 2 Cases

Autor: Thayná Melo de Lima Morais, Wilson Delgado-Azañero, Oslei Paes de Almeida, Hugo Ghersi Miranda, Ciro Dantas Soares
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Ameloblastic Fibrosarcoma
Pathology
medicine.medical_specialty
Biopsy
Fibrosarcoma
medicine.medical_treatment
Gingiva
Odontogenic Carcinosarcoma
Odontogenic Tumors
Vimentin
Mandible
Pathology and Forensic Medicine
Diagnosis
Differential
Young Adult
03 medical and health sciences
0302 clinical medicine
Carcinosarcoma
stomatognathic system
Radiography
Panoramic
Rhabdomyosarcoma
Atypia
medicine
Premolar
Humans
biology
business.industry
Mouth Mucosa
030206 dentistry
medicine.disease
Magnetic Resonance Imaging
purl.org/pe-repo/ocde/ford#3.01.09 [https]
Radiation therapy
Mandibular Neoplasms
stomatognathic diseases
Clinicopathologic
medicine.anatomical_structure
030220 oncology & carcinogenesis
biology.protein
Immunohistochemistry
Female
Surgery
purl.org/pe-repo/ocde/ford#3.02.11 [https]
Anatomy
Tomography
X-Ray Computed
business
Popis: This study reports 2 odontogenic carcinosarcomas, including the clinicopathologic and immunoprofile characteristics of these rare tumors. The first case occurred in a 22-year-old male presenting a bilobular mass involving the gingiva and bone of the premolar region of the left mandible, with paresthesia of the lower lip. Microscopic examination revealed a tumor similar to ameloblastic fibrosarcoma, with atypical mesenchymal cells; however, the odontogenic epithelium also showed atypia. In the second case, a 16-year-old female had a painless, asymptomatic, large intraosseous mandibular lesion. The patient received radiotherapy to treat a rhabdomyosarcoma of the parotid 13 years before. The tumor was composed of atypical spindle cells, positive for vimentin and smooth muscle actin, intermingled with malignant odontogenic epithelium. Both epithelial and mesenchymal components of the tumors showed high index of p53- and Ki67-positive cells. The first case was diagnosed as odontogenic carcinosarcoma possibly originated from an ameloblastic fibrosarcoma, and the second as de novo odontogenic carcinosarcoma possibly caused by previous radiotherapy.
Databáze: OpenAIRE
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