Natural Surfactant-Based Emulsion Vehicles: A Correlation Between Colloidal Structure and In Vitro Release of Diclofenac Diethylamine
| Autor: | Nada Vučinić-Milanković, Gordana Vuleta, Snežana Savić, Slavica Vučinić |
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| Rok vydání: | 2010 |
| Předmět: |
Polymers and Plastics
sorbitan stearate and sucrose cocoate Alcohol 02 engineering and technology 030226 pharmacology & pharmacy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pulmonary surfactant Stearate Lyotropic Physical and Theoretical Chemistry emulsion water distribution diclophenac diethylamine release Chromatography Sorbitan 021001 nanoscience & nanotechnology Surfaces Coatings and Films Biochemistry chemistry Emulsion Liberation Cetearyl alcohol and cetearyl glycoside natural surfactants 0210 nano-technology Water binding |
| Zdroj: | Journal of Dispersion Science and Technology |
| ISSN: | 1532-2351 0193-2691 |
| DOI: | 10.1080/01932690903224904 |
| Popis: | The need for an official pharmaceutical vehicle or carrier of drug based on natural sugar emulsifiers that protect and regenerate natural barriers of the skin lipid layer is constantly increasing. This article studies the specific structures of emulsions and two manners of water binding that provide prolonged skin moisturization and delayed or prolonged release of drugs insoluble in water. Natural emulsifiers of an alkylpolyglucoside (cetearyl alcohol and cetearyl glycoside) and estar-type (sorbitan stearate and sucrose cocoate) are used for manufacturing vehicle/carriers of drugs (diclofenac diethylamine). Specific hydrofilic groups in emulsifiers, such as glycozide and ester, are capable of binding in different manners and variable quantities of water by hydrogen bonds within the cream, which is responsible for water distribution and prolonged skin moisturization. This lyotropic potential of natural emulsifiersalkylpolyglucoside and estar typemay affect the physical stability of topical vehicles by determining the colloidal structure, further reflecting the drug delivery from the pharmaceutical excipient to the skin. The aim of this article is to evaluate whether the type of emulsifier influences the structural characteristics of emulsion systems and how the content and availability of water within the cream reflects the delivery of diclofenac diethylamine (1.16%) from the topical vehicles. Freeze-fracture transmission electron microscopy, wide-angle x-ray diffraction, thermogravimetric analysis, and continual and oscilatory rheological measurements are employed for characterization of emulsion system colloidal structure. Diclofenac diethylamine release profiles from investigated emulsion systems were evaluated using the rotation paddle apparatus, modified by addition of diffusion cells (enhancer cell). There is an important difference in water distribution within the creams with emulsifiers of different chemical types. In the sample with ester-type sugar emulsifiers, the quantity of interlamellar-bound water is four times less than bulk and secondary water, while in the sample with alkylpolyglucoside emulsifier, approximately two thirds of total water are bound inside the system and one third is poorly bound, that is, bulk water. It can also be seen that diclofenac diethylamine is gradually released from the vehicle during 6 hours of testing. Formulation of topical vehicle as dermopharmaceutical drug carrier system, with natural emulsifier, like cetearyl alcohol, cetearyl glucoside, sorbitan stearate, and sucrose cocoate, is recommended. |
| Databáze: | OpenAIRE |
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