Sleep Quality, Depression, and Cognitive Function in Non-Demented Older Adults
| Autor: | Xin Li, Haobo Zhang, Hao He, Feiyan Duan, Qing Guan, Xiaohui Hu, Yuejia Luo, Ning Ma |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Sleep Wake Disorders Mediation (statistics) Neuropsychological Tests Affect (psychology) 03 medical and health sciences 0302 clinical medicine Cognition Memory medicine Humans Cognitive Dysfunction Effects of sleep deprivation on cognitive performance Depression (differential diagnoses) Aged Sleep disorder Sleep quality Recall Depression General Neuroscience General Medicine medicine.disease Psychiatry and Mental health Clinical Psychology 030104 developmental biology Female Geriatrics and Gerontology Psychology Sleep 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Journal of Alzheimer's disease : JAD. 76(4) |
| ISSN: | 1875-8908 |
| Popis: | Background Both sleep quality and depression could affect cognitive performance in older adults. Previous studies have suggested that there are bi-directional relationships between sleep quality and depression. Possibly, the influence of sleep quality on cognition is partly mediated by depression, and vice versa. Objective We aimed to assess the mediation effects of sleep quality and depression on each other's relationship with various cognitive functions in non-demented older adults. Methods Correlations were examined among sleep quality indices, depressive severity score, and five cognitive functions in 206 cognitively normal (CN) older adults and all participants that included these CN and 40 mild cognitive impairment (MCI) individuals. We then analyzed the mediation effects for the significant cognitive correlations of sleep disturbance and depression using the bias-corrected Bootstrap method in the two populations. Results Both sleep disturbance and depression were significantly correlated with memory recall and processing speed. In CN, depression could mediate the relationships of sleep disturbance with both cognitive functions, while sleep disturbance could only mediate the relationship of depression with processing speed, but not memory recall. However, in all participants, sleep disturbance could mediate the relationships of depression with both cognitive functions. Conclusion Different mediation effects in the two models in CN older adults might suggest differential mechanisms underlying the pathways from sleep disturbance and depression to various cognitive functions. The mediation results in all participants might indicate that the mechanisms underlying the pathways from sleep disturbance and depression to memory recall were different between MCI and CN older adults. |
| Databáze: | OpenAIRE |
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