Caspases as therapeutic targets
| Autor: | Howard O. Fearnhead, B V Howley |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
alzheimers-disease brain
ischemia-reperfusion injury domain-containing protein Reviews Inflammation Disease liver preservation injury Substrate Specificity inhibitors nf-kappa-b medicine Animals Humans transplant Enzyme Inhibitors Caspase programmed cell-death Therapeutic strategy Caspase activity Caspase inhibitors biology apoptosis interleukin-1-beta converting-enzyme mutant huntingtin gamma-inducing factor Cell Biology Caspase Inhibitors Enzyme Activation inflammation Apoptosis Caspases Immunology biology.protein Molecular Medicine medicine.symptom Neuroscience Autoinflammatory Disorders familial mediterranean fever |
| Zdroj: | Journal of Cellular and Molecular Medicine |
| ISSN: | 1582-4934 1582-1838 |
| DOI: | 10.1111/j.1582-4934.2008.00292.x |
| Popis: | The development of small molecules to modulate caspase activity offers a novel therapeutic strategy in the treatment of apoptosis-related and inflammatory diseases. Caspases are key mediators of apoptosis and inflammation; deregulation of their activation or expression can lead to the development of conditions such as neurodegenerative and autoinflammatory disorders. This review details the different caspase-associated disorders while focusing on caspase-1 inhibition as a potential therapeutic strategy. Problems facing the development of effective and safe caspase therapeutics will also be addressed. |
| Databáze: | OpenAIRE |
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