Fully quantitative mapping of abnormal aortic velocity and wall shear stress direction in patients with bicuspid aortic valves and repaired coarctation using 4D flow cardiovascular magnetic resonance

Autor: Aart J. Nederveen, Carmen P.S. Blanken, Pim van Ooij, Maarten Groenink, Emile S. Farag, R. Nils Planken, S. Matthijs Boekholdt
Přispěvatelé: Radiology and Nuclear Medicine, Cardiothoracic Surgery, ACS - Atherosclerosis & ischemic syndromes, Graduate School, ACS - Diabetes & metabolism, ACS - Pulmonary hypertension & thrombosis, ANS - Brain Imaging, AMS - Amsterdam Movement Sciences, AMS - Ageing & Vitality, AMS - Sports, Cardiology, ACS - Heart failure & arrhythmias
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
lcsh:Diseases of the circulatory (Cardiovascular) system
Hemodynamics
Aorta
Thoracic
030204 cardiovascular system & hematology
030218 nuclear medicine & medical imaging
0302 clinical medicine
Bicuspid aortic valve
Bicuspid Aortic Valve Disease
Bicuspid Aortic Valve Disease/diagnostic imaging
Prospective Studies
Aorta
Thoracic/diagnostic imaging
Aorta
Radiological and Ultrasound Technology
medicine.diagnostic_test
Thoracic/diagnostic imaging
Middle Aged
Descending aorta
Cardiology
cardiovascular system
Female
Cardiology and Cardiovascular Medicine
Blood Flow Velocity
Adult
medicine.medical_specialty
Perfusion Imaging
Stress
Aortic Coarctation/diagnostic imaging
Aortic Coarctation
03 medical and health sciences
Young Adult
Predictive Value of Tests
Internal medicine
medicine.artery
medicine
Humans
Radiology
Nuclear Medicine and imaging
Systole
Angiology
business.industry
Research
Magnetic resonance imaging
Blood flow
Mechanical
medicine.disease
Stenosis
lcsh:RC666-701
Regional Blood Flow
Case-Control Studies
Stress
Mechanical
business
Magnetic Resonance Angiography
Zdroj: Journal of cardiovascular magnetic resonance, 23(1):9. BioMed Central
Journal of Cardiovascular Magnetic Resonance
Journal of Cardiovascular Magnetic Resonance, Vol 23, Iss 1, Pp 1-13 (2021)
ISSN: 1097-6647
Popis: Background Helices and vortices in thoracic aortic blood flow measured with 4D flow cardiovascular magnetic resonance (CMR) have been associated with aortic dilation and aneurysms. Current approaches are semi-quantitative or when fully quantitative based on 2D plane placement. In this study, we present a fully quantitative and three-dimensional approach to map and quantify abnormal velocity and wall shear stress (WSS) at peak systole in patients with a bicuspid aortic valve (BAV) of which 52% had a repaired coarctation. Methods 4D flow CMR was performed in 48 patients with BAV and in 25 healthy subjects at a spatiotemporal resolution of 2.5 × 2.5 × 2.5mm3/ ~ 42 ms and TE/TR/FA of 2.1 ms/3.4 ms/8° with k-t Principal Component Analysis factor R = 8. A 3D average of velocity and WSS direction was created for the normal subjects. Comparing BAV patient data with the 3D average map and selecting voxels deviating between 60° and 120° and > 120° yielded 3D maps and volume (in cm3) and surface (in cm2) quantification of abnormally directed velocity and WSS, respectively. Linear regression with Bonferroni corrected significance of P Results The velocity volumes > 120° correlated moderately with the vorticity scores (R ~ 0.50, P 120° did not correlate with quantitative vorticity. For abnormal velocity and WSS deviating between 60° and 120°, moderate correlations were found with aortic diameters (R = 0.50–0.70). For abnormal velocity and WSS deviating > 120°, additional moderate correlations were found with age and with peak velocity (stenosis severity) and a weak correlation with gender. Ensemble maps showed that more than 60% of the patients had abnormally directed velocity and WSS. Additionally, abnormally directed velocity and WSS was higher in the proximal descending aorta in the patients with repaired coarctation than in the patients where coarctation was never present. Conclusion The possibility to reveal directional abnormalities of velocity and WSS in 3D provides a new tool for hemodynamic characterization in BAV disease.
Databáze: OpenAIRE
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