Study of beta-blockers/beta-cyclodextrins inclusion complex by NMR, DSC, X-ray and SEM investigation

Autor:	M. L. Calabrò, Cecilia Rustichelli, Silvana Tommasini, Rita Ficarra, D. Raneri, Maria Cristina Gamberini, D. Di Bella, Paola Ficarra
Rok vydání:	2000
Předmět:	Magnetic Resonance Spectroscopy Scanning electron microscope Clinical Biochemistry Adrenergic beta-Antagonists Analytical chemistry Pharmaceutical Science complexe Calorimetry celiprolol Analytical Chemistry Inclusion compound nmr beta-cyclodextrin chemistry.chemical_compound Differential scanning calorimetry X-Ray Diffraction Drug Discovery sem Molecule Spectroscopy Aqueous solution aqueou Calorimetry Differential Scanning Molecular Structure Chemistry Chemical shift technology industry and agriculture Nuclear magnetic resonance spectroscopy solid state inclusion complexe dsc x-ray dsc atenolol carbohydrates (lipids) inclusion x-ray celiprolol dsc inclusion complex beta-cyclodextrin sem sem investigation nmr dsc x-ray x-ray inclusion complexe atenolol solid state aqueou inclusion complexe Microscopy Electron Scanning Physical chemistry lipids (amino acids peptides and proteins) inclusion complex sem investigation
Zdroj:	Journal of pharmaceutical and biomedical analysis. 23(1)
ISSN:	0731-7085
Popis:	The formation of inclusion complexes between beta-cyclodextrin with the two beta-blockers, atenolol and celiprolol, have been studied in the aqueous environment and in the solid state by nuclear magnetic resonance (NMR) spectroscopy, X-ray, differential scanning calorimetry (DSC) and scanning electron microscopy (SEM) techniques. The magnitude of the chemical shifts of the interior and exterior beta-cyclodextrin protons in the presence of each beta-blocker indicated that these are included within the beta-cyclodextrin cavity. In aqueous solution they form 1:1 complexes. In the solid state the formation of the beta-cyclodextrin/atenolol (celiprolol) complexes is confirmed by X-ray, DSC and SEM, also employed to characterize pure substances and their physical mixtures.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7141a828d430ddeb32c1cbfbcfa8d087 https://pubmed.ncbi.nlm.nih.gov/10898152 Zobrazit plný text záznamu Full Text from ScienceDirect