Higher risk of incident hepatitis C virus coinfection among men who have sex with men, in whom the HIV genetic bottleneck at transmission was wide
| Autor: | Roger D, Kouyos, Andri, Rauch, Dominique L, Braun, Wan-Lin, Yang, Jürg, Böni, Sabine, Yerly, Thomas, Klimkait, Vincent, Aubert, Cyril, Shah, Helen, Kovari, Alexandra, Calmy, Matthias, Cavassini, Manuel, Battegay, Pietro L, Vernazza, Enos, Bernasconi, Bruno, Ledergerber, Huldrych F, Günthard, S, Yerly |
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| Přispěvatelé: | University of Zurich, Kouyos, R D |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
10028 Institute of Medical Virology
hepatitis C virus Male transmission bottleneck viruses HIV Infections medicine.disease_cause Men who have sex with men 10234 Clinic for Infectious Diseases Cohort Studies 0302 clinical medicine Switzerland/epidemiology Genotype Prevalence Immunology and Allergy 030212 general & internal medicine ddc:616 0303 health sciences Transmission (medicine) Coinfection Incidence Hepatitis C/epidemiology/transmission virus diseases Hepatitis C 3. Good health Infectious Diseases 2723 Immunology and Allergy Switzerland Adult Sexual transmission Hepatitis C virus 610 Medicine & health HIV Infections/complications Risk Assessment 03 medical and health sciences medicine Coinfection/epidemiology Humans Homosexuality Male 030304 developmental biology business.industry HIV 2725 Infectious Diseases medicine.disease Virology sexual transmission Population bottleneck 570 Life sciences biology business |
| Zdroj: | The Journal of Infectious Diseases, Vol. 210, No 10 (2014) pp. 1555-61 Journal of Infectious Diseases, vol. 210, no. 10, pp. 1555-1561 The Journal of infectious diseases JOURNAL OF INFECTIOUS DISEASES |
| ISSN: | 0022-1899 |
| Popis: | BACKGROUND: High-risk sexual behaviors have been suggested as drivers of the recent dramatic increase of sexually transmitted hepatitis C virus (HCV) among human immunodeficiency virus (HIV)-infected men who have sex with men (MSM). METHODS: We assessed the association between the genetic bottleneck of HIV at transmission and the prevalence and incidence of HCV coinfection in HIV-infected MSM from the Swiss HIV Cohort Study (SHCS). As a proxy for the width of the transmission bottleneck, we used the fraction of ambiguous nucleotides detected by genotypic resistance tests sampled during early HIV infection. We defined a broad bottleneck as a fraction of ambiguous nucleotides exceeding a previously established threshold (0.5%). RESULTS: From the SHCS, we identified 671 MSM with available results of HCV serologic tests and with an HIV genotypic resistance test performed during early HIV infection. Of those, 161 (24.0%) exhibited a broad HIV transmission bottleneck, 38 (5.7%) had at least 1 positive HCV test result, and 26 (3.9%) had an incident HCV infection. Individuals with broad HIV transmission bottlenecks exhibited a 2-fold higher odds of having ever experienced an HCV coinfection (odds ratio, 2.2 [95% confidence interval {CI}, 1.1-4.3]) and a 3-fold higher hazard of having an incident HCV infection (hazard ratio, 3.0 [95% CI, 1.4-6.6]) than individuals with narrow HIV transmission bottlenecks. CONCLUSIONS: Our results indicate that the currently occurring sexual spread of HCV is focused on MSM who are prone to exhibit broad HIV transmission bottlenecks. This is consistent with an important role of high-risk behavior and mucosal barrier impairment in the transmission of HCV among MSM. |
| Databáze: | OpenAIRE |
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