Cognition and HPA axis reactivity in mildly to moderately depressed outpatients. A case–control study

Autor:	Poul Videbech, Jesper Krogh, Merete Nordentoft, Martin Balslev Jørgensen, Anne Helene Garde, Signe Groth Renvillard
Rok vydání:	2012
Předmět:	Adult Male Hypothalamo-Hypophyseal System Saliva medicine.medical_specialty Hydrocortisone Pituitary-Adrenal System Dexamethasone Cognition Memory Outpatients Melancholia medicine Humans skin and connective tissue diseases Psychiatry Reactivity (psychology) Glucocorticoids Depression (differential diagnoses) Depression Case-control study stomatognathic diseases Psychiatry and Mental health Case-Control Studies Female sense organs medicine.symptom Cognition Disorders Psychology medicine.drug
Zdroj:	Krogh, J, Videbech, P, Renvillard, S G, Garde, A H, Jørgensen, M B & Nordentoft, M 2012, ' Cognition and HPA axis reactivity in mildly to moderately depressed outpatients : a case-control study ', Nordic Journal of Psychiatry. Supplement, vol. 66, no. 6, pp. 414-21 . https://doi.org/10.3109/08039488.2012.665081
ISSN:	1502-4725 0803-9488
DOI:	10.3109/08039488.2012.665081
Popis:	Patients with depression display neurobiological changes of the hypothalamic-pituitary axis as well as cognitive disturbances.To assess any association between hypothalamus-pituitary-adrenal (HPA) axis reactivity and memory-related cognitive functions.Depressed outpatients (n = 83, ICD-10) were group-matched to healthy controls (n = 33), and tested on a number of cognitive domains. Salivary samples were collected at awakening, 30 min later and at 22:00 h. At 23:00 h, the participants ingested 1.0 mg of dexamethasone, and three saliva samples were collected the following day at the same times.Patients and controls did not differ on any memory-related cognitive skills. After dexamethasone the cortisol level was 1.7 nmol/l higher (95% CI 0.0-2.8, P = 0.05) in depressed patients compared with controls. In the control group, but not in the patients, a positive association between post-DST cortisol and Rey's Complex figure test (1.3; 95% CI 0.3-3.6; P = 0.02) was found. We found no significant associations between other memory functions and cortisol measures.Contrary to our hypothesis, we found a positive association between cortisol levels after dexamethasone and visuo-spatial memory primarily driven by the healthy controls. Otherwise, no association were found between HPA axis reactivity and memory-related cognitive function.
Databáze:	OpenAIRE
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