Linking COVID-19 and Heme-Driven Pathophysiologies: A Combined Computational–Experimental Approach
| Autor: | Alpha Tom Kodamullil, Daniel Domingo-Fernández, Diana Imhof, Milena S. Detzel, Martin Hofmann-Apitius, Marie Thérèse Hopp, Benjamin Franz Schmalohr, Regina Graf, Yojana Gadiya |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Models Molecular cardiovascular risk Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Inflammation Plasma protein binding Computational biology pathway networks Biology Biochemistry Hemolysis Models Biological Microbiology Article heme-binding motifs 03 medical and health sciences chemistry.chemical_compound Viral Proteins 0302 clinical medicine medicine Humans In patient Protein Interaction Maps coagulation heme Molecular Biology Heme SARS-CoV-2 Serine Endopeptidases Computational Biology biomarkers COVID-19 Experimental validation medicine.disease QR1-502 030104 developmental biology chemistry 030220 oncology & carcinogenesis Host-Pathogen Interactions Angiotensin-Converting Enzyme 2 medicine.symptom Protein Binding |
| Zdroj: | Biomolecules, Vol 11, Iss 644, p 644 (2021) Biomolecules Volume 11 Issue 5 |
| Popis: | The SARS-CoV-2 outbreak was declared a worldwide pandemic in 2020. Infection triggers the respiratory tract disease COVID-19, which is accompanied by serious changes in clinical biomarkers such as hemoglobin and interleukins. The same parameters are altered during hemolysis, which is characterized by an increase in labile heme. We present two computational–experimental approaches aimed at analyzing a potential link between heme-related and COVID-19 pathophysiologies. Herein, we performed a detailed analysis of the common pathways induced by heme and SARS-CoV-2 by superimposition of knowledge graphs covering heme biology and COVID-19 pathophysiology. Focus was laid on inflammatory pathways and distinct biomarkers as the linking elements. In a second approach, four COVID-19-related proteins, the host cell proteins ACE2 and TMPRSS2 as well as the viral proteins 7a and S protein were computationally analyzed as potential heme-binding proteins with an experimental validation. The results contribute to the understanding of the progression of COVID-19 infections in patients with different clinical backgrounds and may allow for a more individual diagnosis and therapy in the future. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|