Quantitative determination of nitroglycerin in human plasma by capillary gas chromatography negative ion chemical ionization mass spectrometry
| Autor: | Aslak Sothmann, Pekka Ottoila, Jyrki Taskinen |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Chemical ionization
Chromatography Calibration curve Administration Topical Analytical chemistry Mass spectrometry Capillary electrophoresis–mass spectrometry Gas Chromatography-Mass Spectrometry Ion Pentane chemistry.chemical_compound Nitroglycerin chemistry Humans Direct electron ionization liquid chromatography–mass spectrometry interface Gas chromatography–mass spectrometry Spectroscopy |
| Zdroj: | Biomedical mass spectrometry. 9(3) |
| ISSN: | 0306-042X |
| Popis: | A quantitative method for determination of nitroglycerin in human plasma was developed. Nitroglycerin and the internal standard (butane-1,2,4-triyl trinitrate) were extracted from plasma with pentane. The extracts were analysed by gas chromatography mass spectrometry using fused silica capillary columns and electron capture negative ion chemical ionization. The quantitation limit of the method was about 50 pg ml-1. Linear calibration curves were obtained in the range of 50-1600 pg ml-1. Precision at the level of 100 pg ml-1 was 4%. |
| Databáze: | OpenAIRE |
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