Non-occupational post-exposure prophylaxis for HIV at St Michael's Hospital, Toronto: a retrospective review of patient eligibility and clinical outcomes
| Autor: | Kevin Gough, Deborah Yoong, M Dimeo, A C H Chan, Darrell H. S. Tan |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Risk Canada medicine.medical_specialty Time Factors Anti-HIV Agents medicine.medical_treatment Human immunodeficiency virus (HIV) Non occupational Eligibility Determination HIV Infections Dermatology medicine.disease_cause Asymptomatic Drug Administration Schedule Internal medicine Outcome Assessment Health Care medicine Humans Pharmacology (medical) In patient Post-exposure prophylaxis Intensive care medicine Referral and Consultation Retrospective Studies Retrospective review business.industry Public Health Environmental and Occupational Health medicine.disease Infectious Diseases Patient Compliance Drug Therapy Combination Female Syphilis medicine.symptom Post-Exposure Prophylaxis business Follow-Up Studies Program Evaluation Cohort study |
| Zdroj: | International Journal of STD & AIDS. 24:393-397 |
| ISSN: | 1758-1052 0956-4624 |
| DOI: | 10.1177/0956462412472826 |
| Popis: | Stringent eligibility criteria, drug costs and antiretroviral toxicities are challenges in delivering HIV non-occupational post-exposure prophylaxis (nPEP). We reviewed patients’ nPEP eligibility and clinical outcomes at St Michael's Hospital, Toronto, Canada to identify opportunities for improvement. Of 241 patients, 59%, 36% and 6% presented for high- (receptive anal/vaginal, blood), medium- (insertive anal/vaginal) and low-risk (oral) sexual exposures, respectively, and nearly all (93%) presented within 72 hours. Of 205 patients given nPEP, 20 were known to have discontinued nPEP prematurely: three due to costs but none due to toxicities. Two HIV seroconversions occurred in patients with suspected ongoing potential exposures. Five asymptomatic syphilis diagnoses were made among 71 tested. Only 39% and 19% of nPEP patients returned to our institution for follow-up at 3–4 and six months, respectively. Our findings underscore the feasibility and importance of nPEP programmes to HIV and sexually transmitted infection control, while identifying opportunities for improvement. |
| Databáze: | OpenAIRE |
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