Longitudinal analysis of symptom-based clustering in patients with primary Sjogren’s syndrome: a prospective cohort study with a 5-year follow-up period

Autor:	Mi Sun Park, Seung-Ki Kwok, Sung Hwan Park, Jennifer Lee, Youngjae Park, Hyeon Woo Yim
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	medicine.medical_specialty Disease General Biochemistry Genetics and Molecular Biology Cohort Studies Cluster analysis Internal medicine Latent class analysis medicine Humans In patient Prospective Studies Prospective cohort study Depression (differential diagnoses) business.industry Research General Medicine Latent class model eye diseases stomatognathic diseases Sjogren's Syndrome Cohort Anxiety Sjogren’s syndrome Medicine medicine.symptom business Follow-Up Studies
Zdroj:	Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-8 (2021) Journal of Translational Medicine
ISSN:	1479-5876
Popis:	Background Sjogren’s syndrome (SS) is a heterogenous disease with various phenotypes. We aimed to provide a relevant subclassification based on symptom-based clustering for patients with primary (p) SS. Methods Data from patients in a prospective pSS cohort in Korea were analysed. Latent class analysis (LCA) was performed using patient reported outcomes, including pain, fatigue, dryness, and anxiety/depression. Clinical and laboratory differences between the classes were analysed. Latent transition analysis (LTA) was applied to the longitudinal data (annually for up to 5 years) to assess temporal stability of the classifications. Results LCA identified three classes among 341 patients with pSS (i.e., ‘high symptom burden’, ‘dryness dominant’, ‘low symptom burden’). Each group had distinct laboratory and clinical phenotypes. LTA revealed that class membership remained stable over time. Baseline class predicted future salivary gland function and damage accrual represented by a Sjogren’s syndrome disease damage index. Conclusion Symptom-based clustering of heterogenous patients with primary Sjogren’s syndrome provided a relevant classification supported by temporal stability over time and distinct phenotypes between the classes. This clustering strategy may provide more homogenous groups of pSS patients for novel treatment development and predict future phenotypic evolvement.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7136beeedfb27380e75cff7c39bdb807 https://doaj.org/article/979607c79488498c83159a8cabbc2f0a Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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