A disposable lab-on-a-chip platform with embedded fluid actuators for active nanoliter liquid handling
| Autor: | Aman Russom, Volker Nock, Patrick Griss, Göran Stemme, Björn Samel |
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| Rok vydání: | 2006 |
| Předmět: |
Materials science
Microfluidics Biomedical Engineering Micropump Nanotechnology Chemistry Techniques Analytical Specimen Handling Microsphere law.invention Sample volume law Hardware_INTEGRATEDCIRCUITS Disposable Equipment Biochip Molecular Biology business.industry Microchemistry Equipment Design Microfluidic Analytical Techniques Lab-on-a-chip Equipment Failure Analysis Solutions Embedded system Actuator business |
| Zdroj: | Biomedical Microdevices. 9:61-67 |
| ISSN: | 1572-8781 1387-2176 |
| DOI: | 10.1007/s10544-006-9015-5 |
| Popis: | In this work we present the development of a disposable liquid handling lab-on-a-chip (LOC) platform with embedded actuators for applications in analytical chemistry. The proposed platform for nanoliter liquid handling is based on a thermally responsive silicone elastomer composite, consisting of PDMS and expandable microspheres. In our LOC platform, we integrate active dosing, transportation and merging of nanoliter liquid volumes. The disposable platform successfully demonstrates precise sample volume control with smart microfluidic manipulation and on-chip active microfluidic components. It is entirely fabricated from low-cost materials using wafer-level processing. Moreover, an enzymatic reaction and real-time detection was successfully conducted to exemplify its applicability as an LOC. |
| Databáze: | OpenAIRE |
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