Prognostic and diagnostic value of [18F]FDG-PET/CT in restaging patients with small cell lung carcinoma: an Italian multicenter study

Autor: Stefano Fanti, Laura Evangelista, Ilaria Schiorlin, Orazio Schillaci, Aurora Kokomani, Agostino Chiaravalloti, Pierpaolo Alongi, Giacomo Maria Lima, Simone Margotti, Stefano Panareo, Alfonso Ciaccio, Natale Quartuccio, Federica Scalorbi, Giuseppe Rubini, Artor Niccoli Asabella, Davide Cardile, Lea Cuppari, Sara Pacella, Giulia Di Pierro, Corinna Altini, Sergio Baldari, Riccardo Laudicella, Flavia Linguanti, Cristina E. Popescu, Alessandro Lambertini, Salvatore Scalisi, Letterio Sturiale, Federico Caobelli, Antonio Vento, Angelina Cistaro
Přispěvatelé: Quartuccio, N, Evangelista, L, Alongi, P, Caobelli, F, Altini, C, Cistaro, A, Lambertini, A, Schiorlin, I, Popescu, C, Linguanti, F, Laudicella, R, Scalorbi, F, Di Pierro, G, Asabella, A, Cuppari, L, Margotti, S, Lima, G, Scalisi, S, Pacella, S, Kokomani, A, Ciaccio, A, Sturiale, L, Vento, A, Cardile, D, Baldari, S, Panareo, S, Fanti, S, Rubini, G, Schillaci, O, Chiaravalloti, A, Quartuccio N, Evangelista L, Alongi P, Caobelli F, Altini C, Cistaro A, Lambertini A, Schiorlin I, Popescu CE, Linguanti F, Laudicella R, Scalorbi F, Di Pierro G, Asabella AN, Cuppari L, Margotti S, Lima GM, Scalisi S, Pacella S, Kokomani A, Ciaccio A, Sturiale L, Vento A, Cardile D, Baldari S, Panareo S, Fanti S, Rubini G, Schillaci O, Chiaravalloti A
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Adult
Male
medicine.medical_specialty
overall survival
Image Processing
PET computed tomography
Kaplan-Meier Estimate
smoking
Disease-Free Survival
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Computer-Assisted
Fluorodeoxyglucose F18
Neoplasms
Positron Emission Tomography Computed Tomography
medicine
Image Processing
Computer-Assisted
Initial treatment
fluorine-18-fluorodeoxyglucose
prognosis
progression-free survival
small cell lung cancer
Female
Humans
Italy
Neoplasm Staging
Retrospective Studies
Small Cell Lung Carcinoma
Radiology
Nuclear Medicine and imaging
Progression-free survival
neoplasms
business.industry
SCLC
Retrospective cohort study
General Medicine
respiratory tract diseases
Patient management
Multicenter study
fluorine-18-fluorodeoxyglucose
overall survival
PET computed tomography
prognosis
progression-free survival
small cell lung cancer
smoking
030220 oncology & carcinogenesis
Fdg pet ct
Radiology
Non small cell
business
Popis: Background: The presence of residual disease after initial treatment in small cell lung cancer (SCLC) influences prognosis and impacts patient management. To date, few data exist on the value of fluorine-18-fluorodeoxyglucose ([F]FDG)-PET/computed tomography (CT) in SCLC at restaging. Therefore, in restaging patients with SCLC, we aimed to (a) evaluate the prognostic value yielded by [F]FDG-PET/CT and (b) assess the diagnostic agreement between [F]FDG-PET/CT and contrast-enhanced computed tomography (ceCT). Patients and methods: From a multicenter database, we evaluated 164 patients with SCLC who underwent [F]FDG-PET/CT for restaging purposes. PET scans were evaluated visually to identify the presence of recurrence. For each patient, the maximum and the mean standardized uptake value (SUVmax and SUVmean, respectively), metabolic tumor volume, and total lesion glycolysis were calculated, taking into account the lesion with the highest [F]FDG uptake (namely, the index lesion) in the local recurrences, lymph node involvement, and distant metastasis categories. Kaplan-Meier curves were computed to assess the effects of [F]FDG-PET/CT findings on overall survival (OS) and progression-free survival. Furthermore, the agreement between PET/CT and ceCT in detecting metastases was evaluated in 119 patients on a patient-based analysis (Cohen's κ; P < 0.05). Results: The presence of metastatic lesions at [F]FDG-PET/CT was associated with a significantly shorter OS (P = 0.039) and progression-free survival (P < 0.001). Higher SUVmax showed a trend toward a shorter OS (P = 0.065). The K-agreement between ceCT and PET/CT in recurrent SCLC was 0.37 (P < 0.001). PET/CT and ceCT showed the same number of lesions in 52 (43.7%) patients, whereas PET/CT detected additional lesions in 35 (29.4%) patients. Conclusion: Detection of metastatic lesions at restaging by [F]FDG-PET/CT can predict a higher rate of progression and negatively influence OS in patients with SCLC. [F]FDG-PET/CT and ceCT seem to be complementary imaging modalities in patients with metastatic SCLC.
Databáze: OpenAIRE
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