Association of neuropeptides with Th1/Th2 balance and allergic sensitization in children

Autor: Heidrun Behrendt, T. Giese, Roel P. F. Schins, Stefan Röder, Gunda Herberth, Irina Lehmann, Annegret Weber, C. Daegelmann, Ursula Krämer, Michael Borte
Rok vydání: 2006
Předmět:
Male
medicine.medical_specialty
Allergy
T cell
Immunology
Vasoactive intestinal peptide
Suppressor of Cytokine Signaling Proteins
GATA3 Transcription Factor
Substance P
Immunoglobulin E
Allergic sensitization
Interferon-gamma
Suppressor of Cytokine Signaling 1 Protein
Th2 Cells
Immune system
Internal medicine
Hypersensitivity
medicine
Humans
Immunology and Allergy
RNA
Messenger
Child
Sensitization
biology
Reverse Transcriptase Polymerase Chain Reaction
business.industry
Neuropeptides
Interleukin-9
FOXP3
Forkhead Transcription Factors
Th1 Cells
medicine.disease
Logistic Models
Endocrinology
medicine.anatomical_structure
Suppressor of Cytokine Signaling 3 Protein
biology.protein
Female
Interleukin-4
Interleukin-5
Somatostatin
business
Biomarkers
Food Hypersensitivity
Vasoactive Intestinal Peptide
Zdroj: Clinical & Experimental Allergy. 36:1408-1416
ISSN: 1365-2222
0954-7894
DOI: 10.1111/j.1365-2222.2006.02576.x
Popis: Summary Background Among neurogenic factors, the neuropeptides have an important regulatory influence on immune system activity and may lead to allergic sensitization. Objective The aim of our study was to investigate the relationship of the neuropeptides vasoactive intestinal peptide (VIP), somatostatin (SOM) and substance P (SP) on modulation of Th1/Th2 balance and allergic sensitization in children. Methods Within the LISAplus (Life style–Immune system–Allergy) study, blood samples of 321 six-year-old children were analysed for concentration of neuropeptides, Th1 and Th2 cytokines, transcription factors for T cell regulation and suppressors of cytokine signalling. In addition, samples were screened for specific IgE against inhalant and food allergens. Results Children with high SOM values showed a Th2 polarization and a reduced expression of FOXP3, the marker for regulatory T cells. High (VIP) levels correlated inversely with the expression of T cell transcription factors (Tbet and SOCS3). In contrast, elevated levels of SP were associated with reduced GATA3 and SOCS3 expression and with increased IFN-γ concentrations. Allergic sensitization was more prevalent in children with higher SOM and VIP concentrations but not associated with SP levels. Conclusion Our data reveal an association between neuropeptides and modulatory effects on immune cells in vivo, especially on Th1/Th2 balance with a correlation to allergic sensitization in children. We suggest that elevated SOM and VIP concentrations and the inducing factors should be considered as allergy risk factors.
Databáze: OpenAIRE
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