No increased prevalence of adrenocortical insufficiency in human immunodeficiency virus-associated tuberculosis
| Autor: | M.P. Hawken, J. Kimari, J. G. Raynes, Willie Githui, Charles F. Gilks, P. Broadbent, L.S. Otieno, J.S. Morris, E S Juma, E.W. Kariuki, K. P. W. J. Mcadam, S. Gathua, J. Ojoo, L.N. Thiong'o |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Tuberculosis Adolescent Hydrocortisone AIDS-Related Opportunistic Infections Immunology Human immunodeficiency virus (HIV) medicine.disease_cause Microbiology Pulmonary tuberculosis Internal medicine Adrenal Glands Humans Medicine Tuberculosis Pulmonary Adrenocortical Insufficiency Aged Aged 80 and over business.industry Significant difference virus diseases Middle Aged medicine.disease HIV-1 Female business Complication medicine.drug |
| Zdroj: | Tubercle and Lung Disease. 77:444-448 |
| ISSN: | 0962-8479 |
| DOI: | 10.1016/s0962-8479(96)90118-5 |
| Popis: | Setting: Acute medical wards, Kenyatta National Hospital, Nairobi, Kenya. Objective: To determine the prevalence of adrenocortical insufficiency in human immunodeficiency virus (HIV)-1 infected and non-infected patients with tuberculosis. Design: One hundred and seventy-four patients with proven tuberculosis (90 HIV-1 positive and 84 HIV-1 negative) were assessed for adrenocortical insufficiency with a 30 min synacthen stimulation test. Results: Fifty-one percent of those with pulmonary tuberculosis and 56% of those with extra-pulmonary tuberculosis had a subnormal cortisol response. However there was no statistically significant difference between the HIV-1 infected and non-infected patients in either group. Conclusion: While an impaired cortisol response is common in tuberculosis, it is no more prevalent in HIV-1 infected patients than non-infected patients with tuberculosis. |
| Databáze: | OpenAIRE |
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