Total Body Response to Mechanical Ventilation of Healthy Lungs: an Experimental Study in Piglets
| Autor: | Honomichl P, S Fikrlova, Petr Jehlička, J Kobr, K Pizingerova, Jaroslav Racek, Lumir Sasek, J Fremuth, Topolcan O |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Time Factors Swine Physiology medicine.medical_treatment Renal function Group B Tidal Volume medicine Animals Lung Tidal volume Inflammation Mechanical ventilation business.industry General Medicine Myocardial Contraction Respiration Artificial Diuresis Free water clearance medicine.anatomical_structure Animals Newborn Ventricle Creatinine Anesthesia Ventricular Function Right Breathing Female Inflammation Mediators business Cell Adhesion Molecules Biomarkers Glomerular Filtration Rate |
| Zdroj: | Scopus-Elsevier Europe PubMed Central |
| ISSN: | 1802-9973 0862-8408 |
| Popis: | The objective of our study was to assess the influence of mechanical ventilation on healthy body organs. Fifteen piglets (aged 6 weeks, 19-27 kg) were anesthetized, instrumented, and divided into three groups: Group A – spontaneously breathing, group B – mechanically ventilated with tidal volume 6 ml/kg, and group C – ventilated with tidal volume 10 ml/kg for 12 hours. The parameters of lung, heart, liver and kidney functions neurohumoral regulation and systemic inflammatory reaction were recorded initially (time-1) and after 12 hours (time-12) of mechanical ventilation. At the onset of experiment (time-1) the levels of soluble adhesive molecules were higher (CAM; P |
| Databáze: | OpenAIRE |
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