Total Body Response to Mechanical Ventilation of Healthy Lungs: an Experimental Study in Piglets

Autor: Honomichl P, S Fikrlova, Petr Jehlička, J Kobr, K Pizingerova, Jaroslav Racek, Lumir Sasek, J Fremuth, Topolcan O
Rok vydání: 2010
Předmět:
Zdroj: Scopus-Elsevier
Europe PubMed Central
ISSN: 1802-9973
0862-8408
DOI: 10.33549/physiolres.931752
Popis: The objective of our study was to assess the influence of mechanical ventilation on healthy body organs. Fifteen piglets (aged 6 weeks, 19-27 kg) were anesthetized, instrumented, and divided into three groups: Group A – spontaneously breathing, group B – mechanically ventilated with tidal volume 6 ml/kg, and group C – ventilated with tidal volume 10 ml/kg for 12 hours. The parameters of lung, heart, liver and kidney functions neurohumoral regulation and systemic inflammatory reaction were recorded initially (time-1) and after 12 hours (time-12) of mechanical ventilation. At the onset of experiment (time-1) the levels of soluble adhesive molecules were higher (CAM; P
Databáze: OpenAIRE