Inhibition of c-fos Transcription and Phosphorylation of the Serum Response Factor by an Inhibitor of Phospholipase C-Type Reactions
| Autor: | C Doppler, G Schalasta |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Bridged-Ring Compounds
Serum Response Factor Transcription Genetic Molecular Sequence Data Gene Expression In Vitro Techniques Biology Phospholipase Chromatography Affinity Cell Line Mice Thiocarbamates Proto-Oncogene Proteins Phosphoinositide phospholipase C Serum response factor Animals Phosphorylation Protein kinase A Transcription factor Molecular Biology Diacylglycerol kinase Base Sequence Epidermal Growth Factor Phospholipase C Activator (genetics) Nuclear Proteins Thiones Cell Biology Norbornanes Molecular biology Phosphoric Monoester Hydrolases DNA-Binding Proteins Type C Phospholipases Proto-Oncogene Proteins c-fos Research Article |
| Zdroj: | Molecular and Cellular Biology. 10:5558-5561 |
| ISSN: | 1098-5549 |
| DOI: | 10.1128/mcb.10.10.5558-5561.1990 |
| Popis: | Phospholipase C activity is necessary for transcriptional c-fos activation by providing diacylglycerol as an activator of protein kinase C. We found that transcriptional activation of c-fos and the phosphorylation of its major transcription factor were inhibited by tricyclodecan-9-yl xanthogenate, which blocks phospholipase C-type reactions. Transcription of the c-ras and beta-actin genes in the same cells remained unaffected. |
| Databáze: | OpenAIRE |
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