Volume changes of thalamus, hippocampus and cerebellum are associated with specific CSF profile in MS
| Autor: | Massimiliano Calabrese, Francesco Crescenzo, Francesca B. Pizzini, Albulena Bajrami, Roberta Magliozzi, Damiano Marastoni, Anna Isabella Pisani |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Cerebellum
Pathology medicine.medical_specialty Thalamus Hippocampus Neuropathology Grey matter Pathogenesis Multiple sclerosis Multiple Sclerosis Relapsing-Remitting medicine Humans Prospective Studies Gray Matter CSF biomarkers surface-in grey matter damage business.industry Brain medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Neurology Csf biomarkers Neurology (clinical) Atrophy business |
| Popis: | Background: The underlying pathogenesis of surface-in grey matter abnormalities in MS, demonstrated by both neuropathology and advanced MRI analyses, is under investigation and it might be related to CSF-mediated mechanism of inflammation and/or damage. Objective: To examine the link of CSF inflammatory profile with the damage of three regions early-involved in MS and bordering with CSF: thalamus, hippocampus and cerebellum. Methods: In this longitudinal, prospective study, we evaluated, in 109 relapsing–remitting MS patients, at diagnosis and after 2-year follow-up, the association between the baseline CSF level of 19 inflammatory mediators and the volume changes of thalamus, hippocampus, cerebellar cortex and control regions (globus pallidus, putamen). Results: The multivariable analysis showed that the CXCL13 and sCD163 CSF levels at baseline were independent predictors of thalamus ([Formula: see text]; p Conclusion: Our results indicate an association between the CSF inflammatory profile and grey matter volume loss of regions anatomically close to CSF boundaries, thus supporting the hypothesis of a surface-in GM damage in MS. |
| Databáze: | OpenAIRE |
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