Single-cell and population coding of expected reward probability in the orbitofrontal cortex of the rat
| Autor: | Matthijs G. P. Feenstra, Jan Lankelma, E. van Duuren, Cyriel M. A. Pennartz, Ruud N. J. M. A. Joosten, G. van der Plasse |
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| Přispěvatelé: | Cognitive and Systems Neuroscience (SILS, FNWI), Netherlands Institute for Neuroscience (NIN), Anatomy and neurosciences, Medical oncology, NCA - Neurodegeneration, Neuroscience Campus Amsterdam - Neurodegeneration |
| Rok vydání: | 2009 |
| Předmět: |
Male
SDG 16 - Peace Time Factors Population level Movement Population Decision Making Action Potentials Prefrontal Cortex Waiting period Statistics Nonparametric Discrimination Psychological Reward Animals Rats Wistar education Divergence (statistics) Probability Neurons education.field_of_study Brain Mapping Behavior Animal General Neuroscience SDG 16 - Peace Justice and Strong Institutions Olfactory Pathways Articles Reconstruction method Justice and Strong Institutions Outcome (probability) Rats nervous system Odorants Conditioning Operant Orbitofrontal cortex Neural coding Psychology Social psychology Neuroscience psychological phenomena and processes |
| Zdroj: | The Journal of Neuroscience, 29(28), 8965-8976. Society for Neuroscience van Duuren, E, van der Plasse, G, Lankelma, J, Joosten, R N J M, Feenstra, M G P & Pennartz, C M A 2009, ' Single-Cell and Population Coding of Expected Reward Probability in the Orbitofrontal Cortex of the Rat ', Journal of Neuroscience, vol. 29, no. 28, pp. 8965-8976 . https://doi.org/10.1523/JNEUROSCI.0005-09.2009 Journal of Neuroscience, 29, 8965-8976. Society for Neuroscience Journal of Neuroscience, 29(28), 8965-8976. Society for Neuroscience van Duuren, E, van der Plasse, G, Lankelma, J, Joosten, R N J M, Feenstra, M G P & Pennartz, C M A 2009, ' Single-Cell and Population Coding of Expected Reward Probability in the Orbitofrontal Cortex of the Rat ', The Journal of Neuroscience, vol. 29, no. 28, pp. 8965-8976 . https://doi.org/10.1523/JNEUROSCI.0005-09.2009 |
| ISSN: | 0270-6474 |
| DOI: | 10.1523/JNEUROSCI.0005-09.2009 |
| Popis: | The orbitofrontal cortex (OFC) has been implicated in decision-making under uncertainty, but it is unknown how information about the probability or uncertainty of future reward is coded by single orbitofrontal neurons and ensembles. We recorded neuronal ensembles in ratOFCduring an olfactory discrimination task in which different odor stimuli predicted different reward probabilities. Single-unit firing patterns correlated to the expected reward probability primarily within an immobile waiting period before reward delivery but also when the rat executed movements toward the reward site. During these pre-reward periods, a subset ofOFCneurons was sensitive to differences in probability but only very rarely discriminated on the basis of reward uncertainty. In the reward period, neurons responded during presentation or omission of reward or during both types of outcome. At the population level, neurons were characterized by a wide divergence in firing-rate variability attributable to expected probability. A population analysis using template matching as reconstruction method indicated that OFC generates a distributed representation of reward probability with a weak dependence on neuronal group size. The analysis furthermore confirmed that predictive information coded by OFC populations was quantitatively related to reward probability, but not to uncertainty. Copyright © 2009 Society for Neuroscience. |
| Databáze: | OpenAIRE |
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