Deletion of interleukin-18 attenuates abdominal aortic aneurysm formation
| Autor: | Jun Aono, Kayo Takahashi, Mika Hamaguchi, Teruyoshi Uetani, Tomoaki Nagao, Tomoki Sakaue, Haruki Okamura, Jun Suzuki, Takafumi Okura, Chika Suehiro, Shuntaro Ikeda, Osamu Yamaguchi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Systole Common disease Blood Pressure 030204 cardiovascular system & hematology Matrix metalloproteinase Muscle Smooth Vascular Cardiovascular death Pathogenesis 03 medical and health sciences Mice 0302 clinical medicine medicine Animals Aorta Abdominal Cell Proliferation Inflammation business.industry Incidence Macrophages Interleukin-18 Interleukin medicine.disease Angiotensin II Abdominal aortic aneurysm Matrix Metalloproteinases Mice Inbred C57BL 030104 developmental biology Phenotype cardiovascular system Cancer research Interleukin 18 Osteopontin Cardiology and Cardiovascular Medicine business Gene Deletion Aortic Aneurysm Abdominal |
| Zdroj: | Atherosclerosis. 289 |
| ISSN: | 1879-1484 |
| Popis: | Background and aims Abdominal aortic aneurysm (AAA) is a common disease; however, its exact pathogenesis remains unknown, and no specific medical therapies are available. Interleukin (IL)-18 plays a crucial role in atherosclerotic plaque destabilization and is a strong predictor of cardiovascular death. Here, we investigated the role of IL-18 in AAA pathogenesis using an experimental mouse model. Methods and results After infusion of angiotensin II (Ang II) for 4 weeks and β-aminopropionitrile (BAPN) for 2 weeks, 58% of C57/6J wild-type (WT) mice developed AAA associated with enhanced expression of IL-18; however, disease incidence was significantly lower in IL-18−/− mice than in WT mice (p Conclusions These findings indicate that IL-18 plays an important role in the development of AAA by enhancing OPN expression, macrophage recruitment, and MMP activation. Moreover, IL-18 represents a previously unrecognized therapeutic target for the prevention of AAA formation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect