Vasorelaxant and antihypertensive effects of methanolic extract from roots of Laelia anceps are mediated by calcium-channel antagonism
| Autor: | Rolffy Ortiz-Andrade, Rafael Villalobos-Molina, Jorge Vergara-Galicia, Julio Cesar Rivera-Leyva, Samuel Estrada-Soto, Patricia Castillo-España, Maximiliano Ibarra-Barajas, Itzell A. Gallardo-Ortiz |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Contraction (grammar) Vasodilator Agents Vasodilation Blood Pressure Pharmacology Plant Roots Muscle Smooth Vascular Glibenclamide Oral administration Drug Discovery medicine Animals Rats Wistar Orchidaceae Antihypertensive Agents Aorta Chromatography High Pressure Liquid biology Chemistry Calcium channel General Medicine Phenanthrenes biology.organism_classification Calcium Channel Blockers Rats Laelia anceps Calcium Serotonin Antagonism medicine.drug Muscle Contraction |
| Zdroj: | Fitoterapia. 81(5) |
| ISSN: | 1873-6971 |
| Popis: | RMELanc-induced relaxation in aortic rings precontracted with NE, 5-HT and KCl. It also reduced NE-induced transient contraction in Ca 2+ -free solution and inhibited contraction induced by increasing external calcium. Nevertheless, the vasorelaxant effect of RMELanc was not reduced by ODQ, 1-alprenolol, TEA, glibenclamide, and 2-AP. Oral administration of 100 mg/kg of RMELanc exhibited a significant decrease in systolic and diastolic blood pressures in SHR rats. HPLC analysis allowed us to detect the presence of 2,7-dihydroxy-3,4,9-trimethoxyphenantrene ( 1 ), which induced a significant relaxation effect. Therefore, our results suggest that RMELanc induces vasorelaxant and antihypertensive effects by blockade of Ca 2+ channels. |
| Databáze: | OpenAIRE |
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