Some new biologically active metal-based sulfonamide
| Autor: | Moulay H. Youssoufi, Hazoor Ahmad Shad, Taibi Ben Hadda, Zahid H. Chohan |
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| Rok vydání: | 2010 |
| Předmět: |
Stereochemistry
Metal ions in aqueous solution chemistry.chemical_element Microbial Sensitivity Tests Zinc Crystallography X-Ray Medicinal chemistry Anti-Infective Agents Drug Discovery Octahedral molecular geometry Animals Chelation Pharmacology chemistry.chemical_classification Sulfonamides Bacteria Ligand Spectrum Analysis Organic Chemistry Electric Conductivity Fungi General Medicine Condensation reaction Sulfonamide chemistry Metals Artemia Antibacterial activity |
| Zdroj: | European Journal of Medicinal Chemistry. 45:2893-2901 |
| ISSN: | 0223-5234 |
| Popis: | A new series of sulfonamide derived Schiff bases has been synthesized by a condensation reaction of various sulfonamides with aromatic aldehydes. The so obtained sulfonamide were further investigated for their chelation and biological properties with first row d-transition metal ions [cobalt(II), copper(II), nickel(II) and zinc(II)]. The nature of bonding and structure of all the synthesized compounds have been inferred from magnetic susceptibility and conductivity measurements, IR, (1)H and (13)C NMR, electronic spectral, mass spectrometry and CHN analysis data. The structure of ligand, 4-{[(E)-(5-bromo-2-hydroxy phenyl)methylidene]amino}-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide has also been determined by X-ray diffraction method. An octahedral geometry has been suggested for all the complexes. The ligands and their metal complexes have been screened for in vitro antibacterial, antifungal and cytotoxic properties. The result of these studies have revealed that all compounds showed moderate to significant antibacterial activity against one or more bacterial strains and good antifungal activity against various fungal strains. |
| Databáze: | OpenAIRE |
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