Hydrogen sulfide improves neural function in rats following cardiopulmonary resuscitation
| Autor: | Hui Li, Jin‑Gao Wang, Hong Yan Wei, Gang Dai, Ji‑Yan Lin, Xiao Xing Liao, Rong Liu, Min‑Wei Zhang |
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| Rok vydání: | 2014 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty medicine.medical_treatment Enolase Morris water navigation task Sodium hydrosulfide Hippocampal formation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Hydroxylamine Immunology and Microbiology (miscellaneous) medicine Cardiopulmonary resuscitation Saline business.industry General Medicine Articles Pathophysiology Surgery 030104 developmental biology chemistry Anesthesia business 030217 neurology & neurosurgery |
| Zdroj: | Experimental and therapeutic medicine. 11(2) |
| ISSN: | 1792-0981 |
| Popis: | The alleviation of brain injury is a key issue following cardiopulmonary resuscitation (CPR). Hydrogen sulfide (H2S) is hypothesized to be involved in the pathophysiological process of ischemia-reperfusion injury, and exerts a protective effect on neurons. The aim of the present study was to investigate the effects of H2S on neural functions following cardiac arrest (CA) in rats. A total of 60 rats were allocated at random into three groups. CA was induced to establish the model and CPR was performed after 6 min. Subsequently, sodium hydrosulfide (NaHS), hydroxylamine or saline was administered to the rats. Serum levels of H2S, neuron-specific enolase (NSE) and S100β were determined following CPR. In addition, neurological deficit scoring (NDS), the beam walking test (BWT), prehensile traction test and Morris water maze experiment were conducted. Neuronal apoptosis rates were detected in the hippocampal region following sacrifice. After CPR, as the H2S levels increased or decreased, the serum NSE and S100β concentrations decreased or increased, respectively (P |
| Databáze: | OpenAIRE |
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