Characterisation of macrocyclic lactone resistance in two field-derived isolates of Cooperia oncophora
| Autor: | Alison A. Morrison, C.L. McArthur, D.J. Bartley, L. Devin, Jean-François Sutra, Anne Lespine, J. B. Matthews |
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| Přispěvatelé: | Moredun Research Institute [Penicuik, UK] (MRI), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Scottish Government RESAS |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Veterinary medicine 040301 veterinary sciences Nematodes Lactams Macrocyclic [SDV]Life Sciences [q-bio] Drug Resistance Cattle Diseases Cooperia Trichostrongyloidiasis 030308 mycology & parasitology Moxidectin 0403 veterinary science 03 medical and health sciences chemistry.chemical_compound Ivermectin medicine Animals Anthelmintic Macrocyclic lactone Parasite Egg Count Anthelmintic resistance Anthelmintics 0303 health sciences Macrocyclic lactones Ostertagia ostertagi General Veterinary biology Trichostrongyloidea 04 agricultural and veterinary sciences General Medicine biology.organism_classification United Kingdom 3. Good health Nematode chemistry Cooperia oncophora Parasitology Female Cattle Macrolides Dose rate medicine.drug |
| Zdroj: | Veterinary Parasitology Veterinary Parasitology, Elsevier, 2012, 190 (3-4), pp.454-460. ⟨10.1016/j.vetpar.2012.07.022⟩ |
| ISSN: | 0304-4017 |
| DOI: | 10.1016/j.vetpar.2012.07.022⟩ |
| Popis: | International audience; The anthelmintic sensitivity of two field-derived isolates (designated FI001 and FI004) of cattle nematodes from beef farms in Scotland were investigated in a controlled efficacy test (CET). Efficacies of ivermectin pour-on (IVM-PO), IVM injectable (IVM-INJ) and moxidectin pour-on (MOX-PO) formulations were assessed. In each group, five helminth-naive calves were infected experimentally with 50,000 third stage larvae from either isolate and administered with anthelmintic at the manufacturers' recommended dose rate 28 days later. For each isolate, nematode burdens were compared between treatment and control groups to determine efficacy. Nematode species composition, based on data derived from the untreated control groups' burden estimations, were 39 and 14% Cooperia oncophora and 61 and 86% Ostertagia ostertagi for isolates FI001 and FI004, respectively. Macrocyclic lactone resistance in C. oncophora was confirmed for both FI001 and FI004 isolates. Efficacies (as determined by nematode burden analysis) of 4,21 and 31% for FI001, and 10, 1 and 74% for FI004, were obtained for IVM-INJ, IVM-PO and MOX-PO, respectively. Efficacy based on faecal egg count reduction at seven days post anthelmintic administration were 8, 99 and 100% for FI001, and 37, 20 and 100% for FI004 for IVM-INJ, IVM-PO and MOX-PO, respectively. In summary, this study details two macrocyclic lactone resistant isolates of C. oncophora obtained from cattle from two distinct geographical locales in the UK. |
| Databáze: | OpenAIRE |
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