Comparison of hepatic resection and systemic treatment of breast cancer liver metastases: A propensity score matching study
| Autor: | Chang-Ming Zhou, Zhi-Min Shao, Yong Fa Zhang, Qi Pan, Yun Feng, Lu Wang, Yuan Ji, Sheng-Yu Huang, Zheng Li, Ying Zheng, Qiong-Yan Zhang, Xigan He |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
China
medicine.medical_specialty Hepatic resection medicine.medical_treatment Breast Neoplasms Gastroenterology Resection 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine medicine Overall survival Hepatectomy Humans 030212 general & internal medicine Propensity Score business.industry Liver Neoplasms General Medicine Middle Aged medicine.disease Combined Modality Therapy Survival Rate Treatment Outcome Survival benefit 030220 oncology & carcinogenesis Propensity score matching Female Surgery business |
| Zdroj: | The American Journal of Surgery. 220:945-951 |
| ISSN: | 0002-9610 |
| DOI: | 10.1016/j.amjsurg.2020.02.047 |
| Popis: | The role of surgery in breast cancer liver metastases (BCLM) remains elusive, and current application is limited. Our aim is to investigate whether hepatic resection (HR) of BCLM improves survival compared with non-hepatic resection (NHR) treatment.Three hundred and eighty-four patients with BCLM from 2008 to 2018 were divided into two groups. Propensity score matching (PSM) analysis was used to compare the clinical outcomes.After PSM the mean overall survival (OS) and the 1, 3, and 5-year OS rates in HR group were 61.8 months, 92.6%, 54.7% and 54.7%, respectively; while for NHR group these values were 38.6 months, 79.2%, 45.6% and 21.9%, respectively (p 0.007). Multivariate analysis indicated hormonal receptor status (p = 0.039) and hepatic resection (p = 0.032) were independent prognostic factors.Our study revealed that hepatectomy yields a survival benefit safely compared with medical treatments, especially for patients with positive hormonal receptors. |
| Databáze: | OpenAIRE |
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