The expression of p63 in bladder cancer vs. chronic bilharzial bladder
| Autor: | Mahmoud Riad, Mahmoud Daw, Khaled Mursi, Ayman Agag, Olfat Hammam |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
SCC - Squamous cell carcinoma
P63 Pathology medicine.medical_specialty Bladder cancer business.industry Histological type Urology Uroscience Original article Bladder Cancer medicine.disease SCC squamous cell carcinoma TCC - Transitional cell carcinoma TCC transitional cell carcinoma Diagnosis Medicine Immunohistochemistry sense organs Bilharziasis Stage (cooking) CIS carcinoma in situ business |
| Zdroj: | Arab Journal of Urology |
| ISSN: | 2090-5998 2090-598X |
| Popis: | Objective To investigate the immunohistochemical expression of p63 in bladder cancer and the variation of expression in relation to histological type, grade and stage of the tumour, and whether bilharziasis (endemic in Egypt) has an effect on its expression, in an attempt to better understand the tumour behaviour and the possibility of using p63 as a prognostic marker. Patients and methods In a prospective study, biopsies were taken from the bladders of 70 patients, who were divided into three groups; group A comprised 10 with a normal urothelium, group B comprised 20 with chronic cystitis (bilharzial and non-bilharzial) and group C contained 40 with bladder cancer. The biopsies were examined for the expression of p63, using immunohistochemical techniques. Results The mean (SD) ages of groups A, B and C were 45.2 (9.5), 50.5 (11.7) and 60.5 (9.9) years, respectively. There was a statistically significant decrease in the expression and immunoreactivity in group C (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|