Clinical phenotyping of newly diagnosed type 2 diabetes in Yemen
| Autor: | Ahmed Nasser Al-Radaei, Saleh A. Al-Akily, Abdallah A. Gunaid, Mahfouth Abdalla Bamashmus, Mohammed Mohammed Al-Kebsi |
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| Rok vydání: | 2018 |
| Předmět: |
Research design
medicine.medical_specialty clinical features Yemen Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Type 2 diabetes Newly diagnosed Clinical Care/Education/Nutrition 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus Medicine 030212 general & internal medicine HOMA2-modeling business.industry Insulin phenotypes Function group High insulin Insulin sensitivity medicine.disease type 2 diabetes business |
| Zdroj: | BMJ Open Diabetes Research & Care |
| ISSN: | 2052-4897 |
| DOI: | 10.1136/bmjdrc-2018-000587 |
| Popis: | ObjectiveTo identify clinical phenotypes of type 2 diabetes (T2D) among adults presenting with a first diagnosis of diabetes.Research design and methodsA total of 500 consecutive patients were subject to clinical assessment and laboratory investigations. We used data-driven cluster analysis to identify phenotypes of T2D based on clinical variables and Homeostasis Model Assessment (HOMA2) of insulin sensitivity and beta-cell function estimated from paired fasting blood glucose and specific insulin levels.ResultsThe cluster analysis identified three statistically different clusters: cluster 1 (high insulin resistance and high beta-cell function group), which included patients with low insulin sensitivity and high beta-cell function; cluster 2 (low insulin resistance and low beta-cell function group), which included patients with high insulin sensitivity but very low beta-cell function; and cluster 3 (high insulin resistance and low beta-cell function group), which included patients with low insulin sensitivity and low beta-cell function. Insulin sensitivity, defined as median HOMA2-S, was progressively increasing from cluster 1 (35.4) to cluster 3 (40.9), to cluster 2 (76) (pConclusionCluster analysis of newly diagnosed T2D in adults has identified three phenotypes based on clinical variables central to the development of diabetes and on specific clinical variables of each phenotype. |
| Databáze: | OpenAIRE |
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