The effect of an in situ-produced oil shale processing water on metabolism
| Autor: | A. D. Anderson, R. E. Poulson, D. S. Farrier, D. S. North, G. R. Payne, Kenneth F. Nelson |
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| Rok vydání: | 1978 |
| Předmět: |
Male
Cytochrome Health Toxicology and Mutagenesis Zoxazolamine Industrial Waste Hexobarbital In Vitro Techniques Toxicology Retort law.invention Cytochrome P-450 Enzyme System law medicine Animals Inducer Water Pollutants biology Chemistry Ethylmorphine-N-Demethylase Proteins General Medicine Metabolism Ethylmorphine Pollution Rats Petroleum Biochemistry Liver biology.protein Oil shale Water Pollutants Chemical medicine.drug Half-Life |
| Zdroj: | Archives of environmental contamination and toxicology. 7(3) |
| ISSN: | 0090-4341 |
| Popis: | The effects of in situ-produced oil shale retort water on the metabolism of various substrates was studied both in vivo and in vitro. The induction observed in rats was classified as Type I due to an increase in metabolism of hexobarbital and ethylmorphine without subsequent increases in zoxazolamine metabolism. The maximal absorption of the cytochrome-P450-CO complex was observed to be 450 millimicron, also consistent with Type I inducers. Cytochrome P-450 levels were also significantly increased over controls. |
| Databáze: | OpenAIRE |
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