Bifunctional Pyrrolidin-2-one Terminated Manganese Oxide Nanoparticles for Combined Magnetic Resonance and Fluorescence Imaging
| Autor: | Gabriel E. Bertolesi, Abhinandan Banerjee, Barbara Blasiak, Simon Trudel, Aaron R. Purchase, Boguslaw Tomanek, Oliver Calderon, Chang-Chun Ling |
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| Rok vydání: | 2019 |
| Předmět: |
Fluorescence-lifetime imaging microscopy
Materials science Nanoparticle chemistry.chemical_element Contrast Media 02 engineering and technology Manganese 010402 general chemistry Photochemistry 01 natural sciences Fluorescence chemistry.chemical_compound Fluorescence microscope Humans General Materials Science Particle Size Bifunctional health care economics and organizations Optical Imaging technology industry and agriculture Oxides 021001 nanoscience & nanotechnology Magnetic Resonance Imaging 0104 chemical sciences chemistry Manganese Compounds Magnetic nanoparticles Nanoparticles 0210 nano-technology Luminescence HeLa Cells |
| Zdroj: | ACS applied materialsinterfaces. 11(14) |
| ISSN: | 1944-8252 |
| Popis: | Multimodal probes are an asset for simplified, improved medical imaging. In particular, fluorescence and magnetic resonance imaging (MRI) are sought-after combined capabilities. Here, we show that pyrrolidin-2-one-capped manganese oxide nanoparticles (MnOpyrr NPs) combine MRI with fluorescence microscopy to function as efficient bifunctional bio-nanoprobes. We employ a one-pot synthesis for ca. 10 nm MnO NPs, wherein manganese(II) 2,4-pentadionate is thermally decomposed using pyrrolidin-2-one as a solvent and capping ligand. The MnOpyrr NPs are soluble in water without any further postsynthetic modifications. The r1 relaxivity and r2/r1 ratio indicate that these NPs are potential T1 MRI contrast agents at clinical (3 T) and ultrahigh (9.4 T) magnetic fields. Serendipitously, the as-prepared NPs are photoluminescent. The unexpected luminescence is ascribed to the modification of the pyrrolidin-2-one during the thermal treatment. MnOpyrr NPs are successfully used to enable fluorescence microscopy of HeLa c... |
| Databáze: | OpenAIRE |
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