The American Cancer Society Cancer Prevention Study II Nutrition Cohort: rationale, study design, and baseline characteristics

Autor: Eric J. Jacobs, Marjorie L. McCullough, Michael J. Thun, Ann Chao, Eugenia E. Calle, Carmen Rodriguez, Heather Spencer Feigelson, M. Lyn Almon
Rok vydání: 2002
Předmět:
Gerontology
Male
Cancer Research
Databases
Factual
Cohort Studies
Risk Factors
Neoplasms
Surveys and Questionnaires
Cancer screening
Medicine
Nutritional Physiological Phenomena
Prospective Studies
Marriage
Prospective cohort study
Aged
80 and over
American Cancer Society
Anthropometry
Incidence
Middle Aged
European Prospective Investigation into Cancer and Nutrition
Primary Prevention
Blood
Oncology
Research Design
Cohort
Female
Medical Record Linkage
Cohort study
Adult
medicine.medical_specialty
Diet Surveys
Sensitivity and Specificity
Humans
Risk factor
Life Style
Aged
Cancer prevention
business.industry
Racial Groups
Weight change
Mouth Mucosa
Cancer
Reproducibility of Results
Retrospective cohort study
DNA
medicine.disease
United States
Diet
Nutrition Assessment
Epidemiologic Research Design
Family medicine
business
Biomarkers
Follow-Up Studies
Zdroj: Cancer. 94(9)
ISSN: 0008-543X
Popis: BACKGROUND Large-scale, prospective cohort studies have played a critical role in discovering factors that contribute to variability in cancer risk in human populations. Epidemiologists and volunteers at the American Cancer Society (ACS) were among the first to establish such cohorts, beginning in the early 1950s and continuing through the present, and these ACS cohorts have made landmark contributions in many areas of epidemiologic research. METHODS AND RESULTS The Cancer Prevention Study II Nutrition Cohort was established in 1992 and was designed to investigate the relation between diet and other lifestyle factors and exposures and the risk of cancer, mortality, and survival. The cohort includes over 84,000 men and 97,000 women who completed a mailed questionnaire in 1992. New questionnaires are sent to surviving cohort members every other year to update exposure information and to ascertain new occurrences of cancer; a 90% response rate was achieved for follow-up questionnaires in 1997 and 1999. Reported cancers are verified through medical records, registry linkage, or death certificates. The cohort is followed actively for all cases of incident cancer and for all causes of death. Through a collaborative effort among ACS national and division staff, volunteers, and the American College of Surgeons, blood samples were collected from a subgroup of 40,000 cohort members and are in storage at a central repository for future investigation of dietary, hormonal, genetic, and other factors and cancer risk. Collection of DNA samples from buccal cells in an additional 50,000 cohort members is underway currently and will be completed in 2002. CONCLUSIONS This new cohort of both men and women promises to be particularly valuable for the study of cancer occurrence, mortality, and survival as they relate to obesity and weight change, physical activity at various points in life, vitamin supplement use, exogenous hormone use, other medications (such as aspirin and nonsteroidal anti- inflammatory drugs) and cancer screening modalities. Cancer 2002;94:2490–2501. © 2002 American Cancer Society. DOI 10.1002/cncr.101970
Databáze: OpenAIRE
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