Role of Tonsillar IgD+CD27+ Memory B Cells in Humoral Immunity Against Pneumococcal Infection
| Autor: | Masahiro Takizawa, Kazunaga Agematsu, Kazuo Sugane |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Adolescent Palatine Tonsil Immunology Antibody Affinity Somatic hypermutation chemical and pharmacologic phenomena Immunoglobulin D Pneumococcal Infections stomatognathic system immune system diseases medicine Humans Immunology and Allergy Gene B-Lymphocytes biology hemic and immune systems General Medicine Middle Aged Marginal zone Tumor Necrosis Factor Receptor Superfamily Member 7 B-1 cell medicine.anatomical_structure Immunoglobulin M Tonsil Antibody Formation Humoral immunity biology.protein Female Somatic Hypermutation Immunoglobulin Immunologic Memory |
| Zdroj: | Human Immunology. 67:966-975 |
| ISSN: | 0198-8859 |
| Popis: | IgD+CD27+ memory B cells are a major compartment of circulating memory B cells. However, the characteristics of these cells in the tonsils have been unclear. In this study, IgD+CD27+ memory B cells residing in the tonsillar marginal zone were found to exhibit similar characteristics as IgD+CD27+ memory B cells in the periphery, namely large morphology, expression of surface molecules, and hypermutated Ig variable region genes. Furthermore, these IgD+CD27+ memory B cells predominantly produced IgM, including IgM specific against pneumococcal polysaccharides. Taken together, these results provide convincing evidence that tonsillar IgD+CD27+ memory B cells impart protective humoral immunity against pneumococcal infection by producing high-affinity IgM. |
| Databáze: | OpenAIRE |
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