Rett Syndrome: A Timely Review From Recognition to Current Clinical Approaches and Clinical Study Updates
| Autor: | Shannon M. Standridge, Autumn S Ivy |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Basic science business.industry MEDLINE Rett syndrome Disease MeCP2 Protein medicine.disease MECP2 Clinical study Clinical trial 03 medical and health sciences Phenotype 0302 clinical medicine 030225 pediatrics Mutation Pediatrics Perinatology and Child Health Rett Syndrome medicine Humans Neurology (clinical) business Intensive care medicine 030217 neurology & neurosurgery |
| Zdroj: | Seminars in Pediatric Neurology. 37:100881 |
| ISSN: | 1071-9091 |
| Popis: | Since the discovery of the genetic basis of Rett syndrome in 1999, our understanding has grown considerably both in the scientific and the clinical realms. In the last two decades, we have learned about the far-reaching effects of the aberrant MeCP2 protein, the growing list of involved genetic factors, and the genotype-phenotype clinical expression of common MECP2 mutations. This knowledge has led to several basic science research and clinical trials, focusing specifically on emerging treatments of Rett syndrome. As the pathophysiology behind the disease is better understood, treatments aimed at specific molecular targets will become available for clinicians to improve the life of individuals with Rett syndrome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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