Effects of Green Tea Extract on Atorvastatin Pharmacokinetics in Healthy Volunteers
| Autor: | Ahmed M. Donia, Ahmed M Abdelmageed, Noha M. El-Khodary, Khaled S. Abdelkawy, Reham M Abdelaziz |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Clinical chemistry Atorvastatin Cmax Herb-Drug Interactions Organic Anion Transporters Green tea extract Pharmacology 030226 pharmacology & pharmacy Catechin 03 medical and health sciences Young Adult 0302 clinical medicine Pharmacokinetics Double-Blind Method Tandem Mass Spectrometry health services administration medicine Humans heterocyclic compounds Pharmacology (medical) cardiovascular diseases Cross-Over Studies Dose-Response Relationship Drug Tea Chemistry Plant Extracts nutritional and metabolic diseases Middle Aged Crossover study Bioavailability Dose–response relationship 030220 oncology & carcinogenesis Area Under Curve lipids (amino acids peptides and proteins) Hydroxymethylglutaryl-CoA Reductase Inhibitors medicine.drug Chromatography Liquid |
| Zdroj: | European journal of drug metabolism and pharmacokinetics. 45(3) |
| ISSN: | 2107-0180 |
| Popis: | Green tea catechins were recently reported to inhibit drug transporters such as organic anion-transporting polypeptides (OATPs) and metabolic enzymes, affecting the bioavailability of many drugs. This study aimed to evaluate the clinical significance of the effects of different doses of green tea extract on the pharmacokinetic parameters of atorvastatin and to rationalize the associated interaction mechanism. A randomized, double-blind, three-phase crossover study involving 12 healthy volunteers was performed. Participants received a single dose of atorvastatin 40 mg alone (control group), atorvastatin 40 mg plus a capsule containing 300 mg of dry green tea extract, or atorvastatin 40 mg plus a capsule containing 600 mg of dry green tea extract. Plasma samples taken from the volunteers were analyzed for atorvastatin using liquid chromatography–tandom mass spectrometry (LC/MS/MS). Compared to atorvastatin alone, the administration of 300 mg or 600 mg of the green tea extract along with atorvastatin decreased the peak plasma concentration (Cmax) of atorvastatin by 25% and 24%, respectively (P |
| Databáze: | OpenAIRE |
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