Incidence of glaucomatous visual field loss after two decades of follow-up

Autor: Albert Hofman, Caroline C W Klaver, Nomdo M. Jansonius, Roger C. W. Wolfs, Henriët Springelkamp, Johannes R. Vingerling, Wishal D. Ramdas
Přispěvatelé: Epidemiology, Ophthalmology, MUMC+: MA UECM Oogartsen ZL (9), RS: FHML non-thematic output, Perceptual and Cognitive Neuroscience (PCN)
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Intraocular pressure
genetic structures
Epidemiology
TENSION GLAUCOMA
Glaucoma
Blood Pressure
Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12]
Rotterdam Study
0302 clinical medicine
OPTIC-NERVE HEAD
Risk Factors
Optic Nerve Diseases
Myopia
030212 general & internal medicine
Netherlands
ASSOCIATIONS
Aged
80 and over
education.field_of_study
Incidence (epidemiology)
Ophthalmic Epidemiology
Incidence
Middle Aged
Visual field
Population Surveillance
Female
OPEN-ANGLE GLAUCOMA
Glaucoma
Open-Angle
Adult
medicine.medical_specialty
Optic nerve
Population
Vision Disorders
PRESSURE
03 medical and health sciences
Tonometry
Ocular
Age Distribution
Ophthalmology
GENERAL ELDERLY POPULATION
medicine
Humans
Risk factor
Sex Distribution
education
METAANALYSIS
Aged
business.industry
medicine.disease
Confidence interval
eye diseases
BARBADOS EYE
BODY-MASS INDEX
030221 ophthalmology & optometry
RISK-FACTORS
Visual Field Tests
Visual Fields
business
Body mass index
Follow-Up Studies
Zdroj: European Journal of Epidemiology, 32(8), 691-699. Springer Netherlands
European Journal of Epidemiology, 32, 8, pp. 691-699
European Journal of Epidemiology
European Journal of Epidemiology, 32, 691-699
European Journal of Epidemiology, 32(8), 691-699. Springer, Cham
European Journal of Epidemiology, 32(8), 691-699. SPRINGER
ISSN: 1573-7284
0393-2990
DOI: 10.1007/s10654-017-0270-y
Popis: Contains fulltext : 182318.pdf (Publisher’s version ) (Open Access) To determine the incidence of glaucomatous visual field loss (GVFL) two decades after the start of the Rotterdam Study, and to compare known risk factors for open-angle glaucoma (OAG) between different clinical manifestations of OAG. Of 6806 participants aged 55 years and older from the population-based Rotterdam Study, 3939 underwent visual field testing at baseline and at least one follow-up round. The ophthalmic examinations included optic disc assessment and measurements of intraocular pressure (IOP), refractive error, diastolic blood pressure (DBP), and height and weight. The incidence rate of GVFL was calculated. Associations with the risk factors age, gender, baseline IOP, family history, myopia, DBP, and body-mass index [BMI] were assessed using Cox regression, with different clinical manifestations of OAG as outcome measure (glaucomatous optic neuropathy (GON), GVFL, GVFL and GON, GVFL without GON, and GON without GVFL). Median follow-up was 11.1 (IQR 6.8-17.2; range 5.0-20.3) years. The incidence rate of GVFL was 2.9 (95% confidence interval 2.4-3.4) per 1000 person years (140 cases with incident GVFL in one (n = 113) or both (n = 27) eyes). Baseline IOP and age were significantly associated with all OAG outcomes (all p < 0.001); BMI showed a non-significant protective effect in all outcomes (p = 0.01 to p = 0.09). Gender, myopia, and DBP were not associated with any outcome. Our study provides an estimate of the long-term incidence of GVFL in a predominantly white population. The development of GVFL was strongly associated with baseline IOP and age. Risk factor profiles were similar for the different outcomes.
Databáze: OpenAIRE
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