Hazards of pulse steroid use in a cohort of Egyptian lupus nephritis patients
| Autor: | Noran O El-Azizi, Amr Abd Elzaher, Hanan Mohamed Farouk, Abdelazeim M. Elhefny, Elham S. Mohammed |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
030203 arthritis & rheumatology
lcsh:Immunologic diseases. Allergy medicine.medical_specialty Proteinuria business.industry Pulse (signal processing) medicine.medical_treatment Medical record Lupus nephritis Immunosuppression medicine.disease Frequent use 03 medical and health sciences 0302 clinical medicine Rheumatology Steroid use Internal medicine Cohort medicine 030212 general & internal medicine medicine.symptom business lcsh:RC581-607 |
| Zdroj: | Egyptian Rheumatologist, Vol 41, Iss 4, Pp 277-281 (2019) |
| ISSN: | 1110-1164 |
| Popis: | Background: Pulse methylprednisolone is a tool for rapid immunosuppression in systemic lupus erythematosus (SLE) patients with life-threatening manifestations. Aim of the work: To assess the effect of the frequent use of high-dose pulse steroids on renal response and to detect any associated hazards in lupus nephritis (LN) patients with a disease duration >3 years. Patients and methods: Medical records of 90 Egyptian LN patients were revised every 6 months for the preceding 3 years. Patients’ examination was followed-up every 6 months for another year. Disease damage and activity (SLEDAI) indices were assessed; criteria for renal response evaluated, relevant laboratory investigations performed, and history of steroid therapy reported. Results: The patients mean age was 30.1 ± 8.3 years, 75 were females (83.3%) and 15 males (16.7%), mean SLEDAI was 7.6 ± 6.9 and damage index was 0.38 ± 0.95. All were on treatment with steroids and immunosuppressives. Those receiving frequent pulse-steroids (n = 71) had a significantly higher proteinuria and both significantly correlated throughout the study course (p |
| Databáze: | OpenAIRE |
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