Endogenous testosterone density is an independent predictor of pelvic lymph node invasion in high-risk prostate cancer: results in 201 consecutive patients treated with radical prostatectomy and extended pelvic lymph node dissection
| Autor: | Antonio Benito Porcaro, Alessandro Tafuri, Andrea Panunzio, Giovanni Mazzucato, Clara Cerrato, Sebastian Gallina, Alberto Bianchi, Riccardo Rizzetto, Nelia Amigoni, Emanuele Serafin, Francesco Cianflone, Rossella Orlando, Ilaria Gentile, Filippo Migliorini, Stefano Zecchini Antoniolli, Giacomo Di Filippo, Matteo Brunelli, Vincenzo Pagliarulo, Maria Angela Cerruto, Alessandro Antonelli |
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| Rok vydání: | 2022 |
| Předmět: |
Male
Urology Percentage of biopsy positive cores density High risk prostate cancer Risk Assessment Prostate specific antigen density Pelvis Prostate volume Tumor load density Predictive Value of Tests Humans Extended pelvic lymph node dissection Testosterone Endogenous testosterone density Aged Retrospective Studies Prostatectomy Prostate cancer Endogenous testosterone Prostate Prostatic Neoplasms Pelvic lymph node invasion Organ Size Middle Aged Radical prostatectomy Nephrology Lymphatic Metastasis Lymph Node Excision Prostate specific antigen |
| Zdroj: | International Urology and Nephrology. 54:541-550 |
| ISSN: | 1573-2584 0301-1623 |
| Popis: | Objective To evaluate the influence of endogenous testosterone density (ETD) on pelvic lymph node invasion (PLNI) in high risk (HR) prostate cancer (PCa) treated with radical prostatectomy (RP) and staged with extended pelvic lymph node dissection (ePLND). Materials and methods ETD was evaluated as the ratio of endogenous testosterone (ET) on prostate volume (PV). HR-PCa was assessed according to the European Association of Urology (EAU) system. The association of ETD and other routinely clinical factors (BPC: percentage of biopsy positive cores; PSA: prostate specific antigen; ISUP: tumor grade system according to the International Society of Urologic Pathology; cT: tumor clinical stage) with the risk of PLNI was assessed by the logistic regression model. Results Overall, 201 out of 805 patients (24.9%) were classified HR and PLNI occurred in 42 subjects (20.9%). On multivariate analysis, PLNI was independently predicted by BPC (OR 1.020; 95% CI 1.006–1.035; p = 0.019), ISUP > 3 (OR 2.621; 95% CI 1.170–5.869; p = 0.019) and ETD (OR 0.932; 95% CI 0.870–0.999; p = 0.045). After categorizing continuous clinical predictors, the risk of PLNI was independently increased by ETD up to the median (OR 2.379; 95% CI 1.134–4.991; p = 0.022), BPC > 50% (OR 3.125; 95% CI 1.520–6.425; p = 0.002) as well as by ISUP > 3 (OR 2.219; 95% CI 1.031–4.776; p = 0.042). Conclusions As ETD measurements decreased, patients were more likely to have PLNI. In HR disease with PLNI, the influence of PCa on ETD should be addressed by higher level studies. |
| Databáze: | OpenAIRE |
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