Prenatal and early life exposures to ambient air pollution and development

Autor: Griffith Bell, Akhgar Ghassabian, Sandie Ha, N. Muscatiello, Edwina Yeung, Erin M. Bell, Tabassum Z. Insaf, Pauline Mendola
Rok vydání: 2019
Předmět:
Neurodevelopment
Air pollution
Reproductive health and childbirth
010501 environmental sciences
medicine.disease_cause
Toxicology
01 natural sciences
Biochemistry
0302 clinical medicine
Child Development
Sustainable Cities and Communities
Pregnancy
2.2 Factors relating to the physical environment
030212 general & internal medicine
Prospective Studies
Aetiology
Prospective cohort study
Child
General Environmental Science
Pediatric
Air Pollutants
Ambient air pollution
Biological Sciences
Early life
Female
Major roadway
Article
03 medical and health sciences
Ozone
Clinical Research
Environmental health
Air Pollution
medicine
Traffic
Humans
Climate-Related Exposures and Conditions
0105 earth and related environmental sciences
business.industry
Prevention
Network data
Infant
Environmental Exposure
medicine.disease
Child development
Good Health and Well Being
Relative risk
Chemical Sciences
New York City
Particulate Matter
business
Environmental Sciences
Zdroj: Environ Res
ISSN: 1096-0953
Popis: BACKGROUND: Residential proximity to major roadways, and prenatal exposures to particulate matter 1000m away from a major roadway, those resided 50–100m [RR: 2.12 (1.00–4.52)] and 100–500m [RR: 2.07 (1.02–4.22)] away had twice the risk of failing the communication domain. Prenatal exposures to both PM(2.5) and ozone during various pregnancy windows had weak but significant associations with failing any developmental domain with effects ranging from 1.6%-2.7% for a 10 μg/m(3) increase in PM(2.5) and 0.7%-1.7% for a 10ppb increase in ozone. Average daily postnatal ozone exposure was positively associated with failing the overall screening by 8 months [3.3% (1.1%-5.5%)], 24 months [17.7% (10.4%-25.5%)], and 30 months [7.6%, (1.3%-14.3%)]. Findings were mixed for postnatal PM(2.5) exposures. CONCLUSIONS: In this prospective cohort study, proximity to major roadway and prenatal/early-life exposures to PM(2.5) and O(3) were associated with developmental delays. While awaiting larger studies with personal air pollution assessment, efforts to minimize air pollution exposures during critical developmental windows may be warranted.
Databáze: OpenAIRE
Externí odkaz: