Prenatal and early life exposures to ambient air pollution and development
Autor: | Griffith Bell, Akhgar Ghassabian, Sandie Ha, N. Muscatiello, Edwina Yeung, Erin M. Bell, Tabassum Z. Insaf, Pauline Mendola |
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Rok vydání: | 2019 |
Předmět: |
Neurodevelopment
Air pollution Reproductive health and childbirth 010501 environmental sciences medicine.disease_cause Toxicology 01 natural sciences Biochemistry 0302 clinical medicine Child Development Sustainable Cities and Communities Pregnancy 2.2 Factors relating to the physical environment 030212 general & internal medicine Prospective Studies Aetiology Prospective cohort study Child General Environmental Science Pediatric Air Pollutants Ambient air pollution Biological Sciences Early life Female Major roadway Article 03 medical and health sciences Ozone Clinical Research Environmental health Air Pollution medicine Traffic Humans Climate-Related Exposures and Conditions 0105 earth and related environmental sciences business.industry Prevention Network data Infant Environmental Exposure medicine.disease Child development Good Health and Well Being Relative risk Chemical Sciences New York City Particulate Matter business Environmental Sciences |
Zdroj: | Environ Res |
ISSN: | 1096-0953 |
Popis: | BACKGROUND: Residential proximity to major roadways, and prenatal exposures to particulate matter 1000m away from a major roadway, those resided 50–100m [RR: 2.12 (1.00–4.52)] and 100–500m [RR: 2.07 (1.02–4.22)] away had twice the risk of failing the communication domain. Prenatal exposures to both PM(2.5) and ozone during various pregnancy windows had weak but significant associations with failing any developmental domain with effects ranging from 1.6%-2.7% for a 10 μg/m(3) increase in PM(2.5) and 0.7%-1.7% for a 10ppb increase in ozone. Average daily postnatal ozone exposure was positively associated with failing the overall screening by 8 months [3.3% (1.1%-5.5%)], 24 months [17.7% (10.4%-25.5%)], and 30 months [7.6%, (1.3%-14.3%)]. Findings were mixed for postnatal PM(2.5) exposures. CONCLUSIONS: In this prospective cohort study, proximity to major roadway and prenatal/early-life exposures to PM(2.5) and O(3) were associated with developmental delays. While awaiting larger studies with personal air pollution assessment, efforts to minimize air pollution exposures during critical developmental windows may be warranted. |
Databáze: | OpenAIRE |
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