The hippocampus may be more susceptible to environmental noise than the auditory cortex
| Autor: | Xiao-Mei Liao, Yun Huang, Shao-Hui Wang, Liang Cheng |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Tau hyperphosphorylation Auditory Pathways Time Factors Hippocampus tau Proteins Environment Biology medicine.disease_cause Auditory cortex Mice 03 medical and health sciences 0302 clinical medicine Noise exposure medicine Animals Phosphorylation Environmental noise Auditory Cortex Sensory Systems Oxidative Stress Noise 030104 developmental biology Acoustic Stimulation Tau phosphorylation Models Animal Lipid Peroxidation Neuroscience 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Hearing Research. 333:93-97 |
| ISSN: | 0378-5955 |
| DOI: | 10.1016/j.heares.2016.01.001 |
| Popis: | Noise exposure can cause structural and functional problem in the auditory cortex (AC) and hippocampus, the two brain regions in the auditory and non-auditory systems respectively. The aim of the present study was to explore which one of these two brain regions may be more susceptible to environmental noise. The AC and hippocampus of mice were separated following 1 or 3 weeks exposure to moderate noise (80 dB SPL, 2 h/day). The levels of oxidative stress and tau phosphorylation were then measured to evaluate the effects by noise. Results showed significant peroxidation and tau hyperphosphorylation in the hippocampus with 1 week of noise exposure. However, the AC did not show significant changes until exposure for 3 weeks. These data suggest that although the hippocampus and AC were affected by moderate noise exposure, the hippocampus in the non-auditory system may have been more vulnerable to environmental noise than the AC. |
| Databáze: | OpenAIRE |
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